{"id":"W4221114949","doi":"10.1016/j.cell.2022.02.013","title":"Mucus sialylation determines intestinal host-commensal homeostasis","year":2022,"lang":"en","type":"article","venue":"Cell","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation; Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health","keywords":"Mucus; Biology; Dysbiosis; Mucin; Microbiology; Mucin 2; Pathogen; Inflammation; Homeostasis; Secretion; Intestinal mucosa; Immunology; Cell biology; Gut flora; Gene; Genetics; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001519303,0.00008418105,0.00006585469,0.00005955325,0.0002135779,0.00002156806,0.0001608843,0.00003529199,0.0005232713],"category_scores_gemma":[0.00005415424,0.00008851563,0.00005277358,0.0001195918,0.00003042765,0.000002350559,0.0002279553,0.0001128705,0.00003717397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002072191,"about_ca_system_score_gemma":0.00005478126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002568936,"about_ca_topic_score_gemma":0.000009911571,"domain_scores_codex":[0.9992242,0.00008038644,0.0001182887,0.0002159448,0.000180152,0.000181006],"domain_scores_gemma":[0.9996062,0.0000117882,0.00004412653,0.0002179298,0.00005836624,0.00006157339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001021594,0.00008581792,0.002290035,0.00001161817,0.000006205673,0.00001140533,0.0000476112,0.00008096937,0.9857097,0.00001104929,0.005531606,0.006111783],"study_design_scores_gemma":[0.000672914,0.0005290359,0.002649141,0.000001744492,0.000005952475,0.0000319825,0.0001815336,0.0007208689,0.7231354,0.00003074168,0.2718581,0.0001826653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940708,0.0003218633,0.0005431462,0.0003064266,0.0001234696,0.0001790393,0.00002122518,0.00001583602,0.00441814],"genre_scores_gemma":[0.9960815,0.00001900546,0.0003900591,0.0002263168,0.000121707,0.00005952187,0.0002019051,0.00001553452,0.002884445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2663265,"threshold_uncertainty_score":0.5729454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.014740072560006,"score_gpt":0.2624464489045645,"score_spread":0.2477063763445585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}