{"id":"W4221115485","doi":"10.1038/s41379-022-01062-2","title":"p53 null phenotype is a “positive result” in urothelial carcinoma in situ","year":2022,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Pathology; Carcinoma in situ; Biology; Phenotype; H&E stain; Frameshift mutation; Carcinoma; Immunostaining; Urothelial Cell; Staining; Immunohistochemistry; Cancer; Bladder cancer; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001737753,0.0001669926,0.0003632075,0.0002295946,0.00006722032,0.000004745801,0.0001093613,0.00008889443,0.0003492064],"category_scores_gemma":[0.00002138553,0.0001671825,0.00006815952,0.0002336282,0.00005797565,0.0000346955,0.0001246188,0.0004022081,0.00004879341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003435913,"about_ca_system_score_gemma":0.0002005356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000727038,"about_ca_topic_score_gemma":0.0004498382,"domain_scores_codex":[0.9984901,0.0001973233,0.0002680318,0.0004729827,0.0002017141,0.0003698739],"domain_scores_gemma":[0.9995136,0.00003515632,0.00004873795,0.0003075893,0.00002708484,0.00006782961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01802072,0.00480097,0.6067921,0.0001299122,0.0001682279,0.03681388,0.1098367,0.0006086826,0.150458,0.0009551993,0.002685395,0.06873021],"study_design_scores_gemma":[0.02535399,0.003654921,0.9415318,0.00005047311,0.0001494348,0.001070131,0.001009231,0.00219464,0.01288498,0.007667435,0.003868246,0.0005646714],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807685,0.0006283743,0.00009449517,0.001728025,0.0002009914,0.0005540435,0.0001631273,0.00002982522,0.0158326],"genre_scores_gemma":[0.9948245,0.00001535132,0.0001383564,0.003536253,0.00008337659,0.0002268823,0.00005340192,0.00003400387,0.00108792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3347398,"threshold_uncertainty_score":0.6817505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01932894497325041,"score_gpt":0.2739760683217456,"score_spread":0.2546471233484952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}