{"id":"W4221115485","doi":"10.1038/s41379-022-01062-2","title":"p53 null phenotype is a “positive result” in urothelial carcinoma in situ","year":2022,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Pathology; Carcinoma in situ; Biology; Phenotype; H&E stain; Frameshift mutation; Carcinoma; Immunostaining; Urothelial Cell; Staining; Immunohistochemistry; Cancer; Bladder cancer; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005087977,0.0004801523,0.0002877053,0.001928621,0.0005398322,0.0009232602,0.0004640812,0.001115882,0.003625656],"category_scores_gemma":[0.002253833,0.0002717556,0.0003020131,0.0008196771,0.001133934,0.0005133782,0.0004955537,0.0005064715,0.000902727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001745821,"about_ca_system_score_gemma":0.0002189641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000333827,"about_ca_topic_score_gemma":0.0003922293,"domain_scores_codex":[0.9995346,0.00007909826,0.00006120645,0.00008949914,0.0001456415,0.0000899959],"domain_scores_gemma":[0.9991494,0.0002434888,0.000246239,0.00007464807,0.0001367108,0.0001495048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002578054,0.0002717818,0.419833,0.0003417237,0.0001287148,0.1028411,0.0007333215,0.0001890833,0.4410002,0.002291971,0.002588484,0.02720263],"study_design_scores_gemma":[0.00006228065,0.001284568,0.5248496,0.00008327669,0.0003805287,0.3572344,0.001694132,0.0008713908,0.1018487,0.002817261,0.008808263,0.00006558904],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877868,0.00119923,0.001281574,0.0005982108,0.000171681,0.00001582089,0.0001689995,0.00008014451,0.008697473],"genre_scores_gemma":[0.9982168,0.000334227,0.0004210432,0.00009743586,0.00005797164,0.000004773278,0.0001010034,0.00001188327,0.0007548683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003625656,"threshold_uncertainty_score":0.01212907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01932894497325041,"score_gpt":0.2739760683217456,"score_spread":0.2546471233484952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}