{"id":"W4221116614","doi":"10.1038/s41467-022-29231-6","title":"Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; University of North Carolina at Chapel Hill; Diabetes Canada; National Institutes of Health; Rheinische Friedrich-Wilhelms-Universität Bonn; Central Michigan University; Joslin Diabetes Center","keywords":"Adipocyte; Glucose homeostasis; Lipolysis; Internal medicine; Endocrinology; Insulin resistance; Receptor; Insulin receptor; Glucose uptake; Insulin; Adipose tissue; Biology; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002694915,0.00007760941,0.0001130738,0.00007013898,0.000167553,0.000009021305,0.0004568855,0.0001209138,0.00007515313],"category_scores_gemma":[0.00004569117,0.00008549974,0.00004484407,0.0001796334,0.00004752587,0.000003193645,0.0005348528,0.0003567244,4.643952e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001699692,"about_ca_system_score_gemma":0.00004767296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003117298,"about_ca_topic_score_gemma":0.00006377262,"domain_scores_codex":[0.9993216,0.0001294822,0.0001801344,0.0001649199,0.00009933822,0.0001045507],"domain_scores_gemma":[0.9991487,0.00003642642,0.00008989733,0.0006339113,0.00005777338,0.00003328207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002773299,0.00006325787,0.0004298316,0.000007588703,0.0000252462,2.366672e-7,0.0002894767,0.00004348978,0.9958423,0.001079398,0.0004899453,0.001701528],"study_design_scores_gemma":[0.0004141868,0.0001187728,0.0004779913,0.00001456551,0.00002055257,0.000009395184,0.0005927233,0.0003431388,0.8335693,0.0001782739,0.1641107,0.0001503874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9549855,0.04365401,0.00007484628,0.0007188024,0.00006954093,0.0001492916,0.00007497535,0.000006490931,0.000266523],"genre_scores_gemma":[0.993544,0.001478593,0.00425721,0.0003841868,0.00002518532,0.00003742748,0.0001921496,0.00001289214,0.00006837035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1636207,"threshold_uncertainty_score":0.3486578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158927207290368,"score_gpt":0.2633155097831512,"score_spread":0.2517262377102475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}