{"id":"W4221119482","doi":"10.1158/1538-7445.sabcs21-pd13-06","title":"Abstract PD13-06: Neoadjuvant giredestrant (GDC-9545) + palbociclib versus anastrozole + palbociclib in postmenopausal women with estrogen receptor-positive, HER2-negative, untreated early breast cancer: Primary analysis of the randomized, open-label, phase II coopERA breast cancer study","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Anastrozole; Palbociclib; Medicine; Breast cancer; Estrogen receptor; Internal medicine; Oncology; Clinical endpoint; Cancer; Estrogen; Aromatase inhibitor; Tamoxifen; Metastatic breast cancer; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002469855,0.001500071,0.002998718,0.0004786624,0.0003397861,0.001248261,0.001221335,0.001205602,0.006410126],"category_scores_gemma":[0.001280739,0.0006490762,0.002130978,0.0006283344,0.0009894304,0.0007105935,0.0004529603,0.003197671,0.001229873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001561276,"about_ca_system_score_gemma":0.00262343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001790887,"about_ca_topic_score_gemma":0.005407177,"domain_scores_codex":[0.9989993,0.0005863459,0.00005190673,0.0001554646,0.00009112305,0.0001158257],"domain_scores_gemma":[0.9989508,0.0001875871,0.0002498252,0.00006645377,0.00007299521,0.0004722376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.961135,0.008023892,0.002459972,0.0005187498,0.00145174,0.00003911771,0.00002882085,0.0006035037,0.004572907,0.00007892594,0.002558308,0.01852913],"study_design_scores_gemma":[0.8501306,0.1365323,0.008171875,0.00005334022,0.001200189,0.00008454596,0.00002751019,0.000567795,0.001175472,0.0001280992,0.001907688,0.00002054214],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727734,0.006685603,0.0007486164,0.0009416764,0.0003627483,0.006147518,0.008147261,0.0002110899,0.003982028],"genre_scores_gemma":[0.9747456,0.002987462,0.002476154,0.001437223,0.0003406091,0.004827082,0.008065579,0.00005036765,0.005069861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006410126,"threshold_uncertainty_score":0.02144402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04047341895383786,"score_gpt":0.385350844696385,"score_spread":0.3448774257425472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}