{"id":"W4221119482","doi":"10.1158/1538-7445.sabcs21-pd13-06","title":"Abstract PD13-06: Neoadjuvant giredestrant (GDC-9545) + palbociclib versus anastrozole + palbociclib in postmenopausal women with estrogen receptor-positive, HER2-negative, untreated early breast cancer: Primary analysis of the randomized, open-label, phase II coopERA breast cancer study","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Anastrozole; Palbociclib; Medicine; Breast cancer; Estrogen receptor; Internal medicine; Oncology; Clinical endpoint; Cancer; Estrogen; Aromatase inhibitor; Tamoxifen; Metastatic breast cancer; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002479853,0.0008274516,0.002747359,0.0009994105,0.00121519,0.0001552766,0.001654317,0.0001485501,0.004658124],"category_scores_gemma":[0.00006791495,0.0005965365,0.0002163907,0.007535209,0.001538969,0.000589242,0.001223721,0.002065201,0.000005674179],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005988935,"about_ca_system_score_gemma":0.004164509,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.07362477,"about_ca_topic_score_gemma":0.006190606,"domain_scores_codex":[0.9904983,0.001879315,0.001313112,0.001606596,0.002802867,0.001899785],"domain_scores_gemma":[0.9951998,0.0007683386,0.000689842,0.001348467,0.001376618,0.00061695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7757715,0.0097709,0.1004128,0.0001578231,0.01503632,0.0003218847,0.01255589,0.007297203,0.03885184,0.00003617973,0.0002431694,0.03954451],"study_design_scores_gemma":[0.5252948,0.007711211,0.4476213,0.0007305355,0.002330502,0.00006655743,0.01194983,0.0003529375,0.002546329,0.00002426856,0.0003925134,0.0009792899],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977898,0.001931864,0.000004257328,0.003863879,0.0002171627,0.00725124,0.008550876,0.00007320989,0.0002095373],"genre_scores_gemma":[0.9873406,0.0008171665,0.00007791978,0.0002945762,0.000181314,0.01020827,0.0002213768,0.0001906266,0.0006681474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3472085,"threshold_uncertainty_score":0.9996486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04047341895383786,"score_gpt":0.385350844696385,"score_spread":0.3448774257425472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}