{"id":"W4221120669","doi":"10.1111/jcmm.17260","title":"Novel chloroquine derivative suppresses melanoma cell growth by DNA damage through increasing ROS levels","year":2022,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"Project 211; National Natural Science Foundation of China","keywords":"Melanoma; Apoptosis; Cancer research; Chloroquine; DNA damage; Flow cytometry; Cell growth; Mutant; Chemistry; Biology; Molecular biology; Immunology; DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005427524,0.0002969812,0.0001406962,0.000203816,0.00009330693,0.00009478899,0.0001531674,0.0001961888,0.0005798491],"category_scores_gemma":[0.00004590911,0.00007160642,0.0001571744,0.00007802281,0.0001029022,0.0001229192,0.00009786255,0.0002694755,0.000105844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001262193,"about_ca_system_score_gemma":0.0001497184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003032054,"about_ca_topic_score_gemma":0.0008450236,"domain_scores_codex":[0.9999675,0.000007193991,0.000002989373,0.000006434535,0.000008315265,0.000007565008],"domain_scores_gemma":[0.9999725,0.000002987766,0.000007623383,0.000001971105,0.00000591865,0.000008931357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001561697,0.000044335,0.0001310161,0.00016241,0.000005037753,0.0001091938,0.000009300356,0.0001046939,0.9970299,0.00006086617,0.00006500716,0.002122035],"study_design_scores_gemma":[0.00008027173,0.001482264,0.002385047,0.0000142192,0.00001847831,0.0004106169,0.00001520048,0.000548565,0.9897775,0.00003012295,0.005229387,0.000008288781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788228,0.01399303,0.003423416,0.0002097821,0.00005772394,0.00009682321,0.0003670026,0.0001191565,0.002910317],"genre_scores_gemma":[0.9917595,0.003377535,0.002932709,0.00009285617,0.00001186135,0.00003382223,0.0002797309,0.000006763227,0.001505292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005798491,"threshold_uncertainty_score":0.001939833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151499369875304,"score_gpt":0.2278742348919947,"score_spread":0.2163592411932417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}