{"id":"W4221123218","doi":"10.3390/cancers14071671","title":"A Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario","funders":"Universidad de Granada; Fundación Ramón Areces","keywords":"XIAP; Apoptosis; Caspase; Inhibitor of apoptosis; Cancer research; Cancer; Tumor necrosis factor alpha; Cancer cell; Activator (genetics); Programmed cell death; Biology; Cell biology; Immunology; Medicine; Internal medicine; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736512,0.0001461076,0.0005926377,0.00004008523,0.00001560392,9.513059e-7,0.0001318918,0.00007949727,0.00003457522],"category_scores_gemma":[0.0000335169,0.00007884208,0.0003815669,0.0001901431,0.0000542887,0.000001190826,0.000143084,0.0001123539,1.262394e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001773786,"about_ca_system_score_gemma":0.0008897153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003366932,"about_ca_topic_score_gemma":0.00001933176,"domain_scores_codex":[0.9991308,0.0001118981,0.0003975821,0.0002000837,0.00008044718,0.0000791519],"domain_scores_gemma":[0.9990126,0.000008316001,0.0006197894,0.0003071944,0.0000321204,0.00002000071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006633424,0.00001013051,0.0000117397,0.04995618,0.00005008573,1.552884e-8,0.00002410381,0.00003613679,0.00298676,0.000001871984,0.0002562122,0.9466601],"study_design_scores_gemma":[0.0001274262,0.0001351689,0.00002000872,0.1093718,0.0001511291,0.000001123755,0.000008170162,0.000007358249,0.008370325,0.000008472898,0.8816675,0.0001314515],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001885806,0.9969338,0.000003601452,0.000003384331,0.0001644804,0.0008552313,0.0001255665,6.907646e-7,0.00002743371],"genre_scores_gemma":[0.00144626,0.998247,0.000006257247,0.000004635256,0.0000383927,0.000177931,0.0000507956,0.00001353729,0.00001516127],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9465287,"threshold_uncertainty_score":0.3215086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03340092475262869,"score_gpt":0.3495268274972619,"score_spread":0.3161259027446333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}