{"id":"W4221123218","doi":"10.3390/cancers14071671","title":"A Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario","funders":"Universidad de Granada; Fundación Ramón Areces","keywords":"XIAP; Apoptosis; Caspase; Inhibitor of apoptosis; Cancer research; Cancer; Tumor necrosis factor alpha; Cancer cell; Activator (genetics); Programmed cell death; Biology; Cell biology; Immunology; Medicine; Internal medicine; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004525895,0.0009949792,0.001223563,0.003057914,0.0002941581,0.0008569718,0.0008749853,0.0008574178,0.004876993],"category_scores_gemma":[0.0007453081,0.0003488471,0.0005182109,0.003616264,0.0003390884,0.001307634,0.000587143,0.00172103,0.002619511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005629612,"about_ca_system_score_gemma":0.0007999182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000717646,"about_ca_topic_score_gemma":0.001501892,"domain_scores_codex":[0.9998201,0.00003037118,0.00003538567,0.00003141324,0.0000674237,0.00001530886],"domain_scores_gemma":[0.9996818,0.0001486986,0.00004936998,0.00001151181,0.00006890995,0.00003971941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009906023,0.00008555511,0.0001219667,0.02474324,0.0001014197,0.0002227993,0.00006379915,0.0004247578,0.001801619,0.002535391,0.06753422,0.9022662],"study_design_scores_gemma":[0.00001775717,0.0001054698,0.0005680305,0.00296313,0.0001106005,0.001125846,0.0000280287,0.00005691676,0.0002782195,0.0008000223,0.9939315,0.00001448926],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008156248,0.9984692,0.0001073454,0.0001525239,0.0003511051,0.000005034519,0.00002185403,0.00001052718,0.0008009121],"genre_scores_gemma":[0.0004157729,0.9983987,0.0001713708,0.0001815898,0.0002543902,0.000007273648,0.00004520816,0.000002115647,0.0005234645],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004876993,"threshold_uncertainty_score":0.01631522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03340092475262869,"score_gpt":0.3495268274972619,"score_spread":0.3161259027446333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}