{"id":"W4221126323","doi":"10.1021/acs.molpharmaceut.1c00918","title":"Biodistribution and Activity of EGFR Targeted Polymeric Micelles Delivering a New Inhibitor of DNA Repair to Orthotopic Colorectal Cancer Xenografts with Metastasis","year":2022,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation","keywords":"PTEN; Tensin; Cancer research; Chemistry; Epidermal growth factor receptor; In vivo; Colorectal cancer; Metastasis; Cancer; Medicine; Receptor; Biology; Signal transduction; Biochemistry; PI3K/AKT/mTOR pathway; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140889,0.0001732436,0.0002490697,0.00008037817,0.00008410172,0.000006591681,0.0001138917,0.00004968353,0.00003018292],"category_scores_gemma":[0.00001615008,0.0001805763,0.0001116004,0.0003290312,0.00007807971,0.000005071143,0.0002240957,0.000109376,1.638499e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003373455,"about_ca_system_score_gemma":0.0002200677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005659591,"about_ca_topic_score_gemma":0.00009142937,"domain_scores_codex":[0.9989426,0.00008972079,0.0001946459,0.0003212473,0.000222519,0.0002292746],"domain_scores_gemma":[0.9994331,0.000006581089,0.0001494949,0.0001828494,0.00008046401,0.0001475079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006248839,0.00009338209,0.001016896,0.00005590194,0.000254562,0.000004179528,0.0001270021,0.000651818,0.9881325,0.000005846714,0.0002769349,0.008756126],"study_design_scores_gemma":[0.0009682795,0.0003484692,0.001125292,0.000009635834,0.0002197755,0.00001593831,0.00006731026,0.0001245739,0.9343091,0.000001137,0.0626253,0.0001851599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853227,0.01172887,0.001810462,0.00009603173,0.0002876538,0.0003523387,0.0003675886,0.00001538147,0.00001893577],"genre_scores_gemma":[0.9979293,0.0006839417,0.0009460447,0.0001316675,0.0001298462,0.00005613787,0.00006283829,0.00002285141,0.00003739235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06234836,"threshold_uncertainty_score":0.736369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261380319709799,"score_gpt":0.2739101609552259,"score_spread":0.2612963577581279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}