{"id":"W4221126323","doi":"10.1021/acs.molpharmaceut.1c00918","title":"Biodistribution and Activity of EGFR Targeted Polymeric Micelles Delivering a New Inhibitor of DNA Repair to Orthotopic Colorectal Cancer Xenografts with Metastasis","year":2022,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation","keywords":"PTEN; Tensin; Cancer research; Chemistry; Epidermal growth factor receptor; In vivo; Colorectal cancer; Metastasis; Cancer; Medicine; Receptor; Biology; Signal transduction; Biochemistry; PI3K/AKT/mTOR pathway; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002322861,0.0002727989,0.0001961473,0.0002222038,0.0000942137,0.0002403991,0.0001728619,0.0002598726,0.001027999],"category_scores_gemma":[0.0001712595,0.0001066687,0.0001315895,0.000114445,0.0001817516,0.0001995723,0.00007009694,0.0004776774,0.000214179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003939175,"about_ca_system_score_gemma":0.0003766817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002766822,"about_ca_topic_score_gemma":0.001836172,"domain_scores_codex":[0.99992,0.00001624897,0.000003749419,0.00002135121,0.00001614033,0.00002256708],"domain_scores_gemma":[0.9999205,0.00001826817,0.00001966845,0.000007048598,0.00001520383,0.00001922975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002523974,0.00006102353,0.00009015941,0.00003254455,0.000007053269,0.00002623288,0.00001976319,0.0002327559,0.9973384,0.00009179326,0.00006742177,0.001780493],"study_design_scores_gemma":[0.00003996087,0.00107562,0.00119407,0.000004514106,0.00002657985,0.0001092317,0.00001615284,0.002578907,0.9937582,0.00002495201,0.001166312,0.000005637335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918494,0.002169715,0.00394366,0.0001279303,0.0000432756,0.00004993723,0.0002012399,0.0001273324,0.001487461],"genre_scores_gemma":[0.9939954,0.0007534006,0.001955937,0.00002557218,0.000007319589,0.00003039278,0.0002027665,0.00003570879,0.002993537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002766822,"threshold_uncertainty_score":0.005501509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261380319709799,"score_gpt":0.2739101609552259,"score_spread":0.2612963577581279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}