{"id":"W4221127390","doi":"10.1038/s41467-022-29142-6","title":"Oncogenic gene expression and epigenetic remodeling of cis-regulatory elements in ASXL1-mutant chronic myelomonocytic leukemia","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Ovarian Cancer Academy; National Center for Advancing Translational Sciences; Medical Research Council; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Mayo Clinic; Center for Individualized Medicine, Mayo Clinic; Henry J. Predolin Foundation for Research in Leukemia","keywords":"Chronic myelomonocytic leukemia; Epigenetics; Mutant; Gene; Regulation of gene expression; Biology; Cancer research; Genetics; Gene expression; Chromatin remodeling; Mutation; Epigenesis; Cell biology; DNA methylation; Myelodysplastic syndromes; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000835209,0.0001647062,0.0003451793,0.0003982936,0.0003332694,0.000009664117,0.0008662603,0.0002005905,0.000105232],"category_scores_gemma":[0.0001794176,0.0001678849,0.00008027704,0.0006441858,0.0001806294,0.00006671783,0.00163634,0.002145145,0.000005672301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003304461,"about_ca_system_score_gemma":0.001560193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000678555,"about_ca_topic_score_gemma":0.00008913601,"domain_scores_codex":[0.9978969,0.0003521767,0.0005726118,0.0003249273,0.0005296607,0.0003237814],"domain_scores_gemma":[0.9970953,0.0002508808,0.0001838519,0.002209129,0.0001350003,0.0001258226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001849565,0.0001935417,0.007069039,0.0000905362,0.00006802502,0.00001462387,0.000569189,0.001064422,0.9797269,0.0003531387,0.0006341988,0.01003147],"study_design_scores_gemma":[0.02322787,0.002117126,0.1506143,0.001187916,0.0005957368,0.000774467,0.00368372,0.3646351,0.3814707,0.00205533,0.0680868,0.001550895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514272,0.04571737,0.00008864795,0.001184387,0.00006250676,0.0007940028,0.00003752987,0.00003855691,0.0006498304],"genre_scores_gemma":[0.9845495,0.004005214,0.01065687,0.0001987025,0.00003799705,0.0001641389,0.0001715114,0.00003992681,0.0001761073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5982561,"threshold_uncertainty_score":0.9319707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02696280171914614,"score_gpt":0.3292543027662127,"score_spread":0.3022915010470666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}