{"id":"W4221132182","doi":"10.1111/mmi.14900","title":"Aluminum hydroxide adjuvant diverts the uptake and trafficking of genetically detoxified pertussis toxin to lysosomes in macrophages","year":2022,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada); Toronto Metropolitan University; The Scarborough Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; University of Toronto; Ryerson University","keywords":"Antigen; Adjuvant; Biology; Pertussis toxin; Endocytosis; Microbiology; Pinocytosis; Immunogenicity; Cell biology; Immunology; Biochemistry; Cell; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055568,0.0001863911,0.0001418067,0.0001075338,0.00009332669,0.0001993566,0.00009687187,0.0002191598,0.0004708518],"category_scores_gemma":[0.00007395717,0.0001004617,0.0002045122,0.00006034649,0.00011537,0.0001455484,0.000154365,0.0002155633,0.0001996229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001506304,"about_ca_system_score_gemma":0.0001479095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000595914,"about_ca_topic_score_gemma":0.0004540103,"domain_scores_codex":[0.9999068,0.00001860688,0.000007201401,0.00001525162,0.00001768807,0.0000346036],"domain_scores_gemma":[0.9999532,0.0000104199,0.00001075339,0.000007175553,0.00001123893,0.000007370375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007894831,0.000009543533,0.0002026357,0.0000141339,0.000001596615,0.00003671584,0.00001176197,0.00002138104,0.9993098,0.00003050034,0.000009007545,0.0002740484],"study_design_scores_gemma":[0.00001254436,0.0002782067,0.005318476,0.000004399181,0.000008040441,0.0001340687,0.00007971082,0.001008936,0.9923307,0.00004464508,0.0007766609,0.000003610426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984893,0.0003467977,0.0007168098,0.00003629576,0.000008343496,0.000005886977,0.00004627023,0.000009605512,0.0003406896],"genre_scores_gemma":[0.9979203,0.0002351588,0.0005820534,0.00004681156,0.000005190373,0.00001128445,0.00007703376,0.000005015176,0.001117169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000595914,"threshold_uncertainty_score":0.001575112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007429549068679754,"score_gpt":0.2148096095418084,"score_spread":0.2073800604731287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}