{"id":"W4221134347","doi":"10.1016/j.jbc.2022.101866","title":"Understanding the physical basis of memory: Molecular mechanisms of the engram","year":2022,"lang":"en","type":"review","venue":"Journal of Biological Chemistry","topic":"Memory and Neural Mechanisms","field":"Neuroscience","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"","keywords":"Engram; Memory consolidation; Neuroscience; Encoding (memory); Recall; Memory formation; Mammalian brain; Long-term memory; Cognitive science; Psychology; Computer science; Cognitive psychology; Hippocampus; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007067157,0.0003018854,0.001284259,0.00003055989,0.0001631773,0.00001472308,0.00165689,0.0002285963,0.0004046842],"category_scores_gemma":[0.001512242,0.000127208,0.00146917,0.0004618254,0.0003064291,0.00002991153,0.000430225,0.001282932,9.065258e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001101437,"about_ca_system_score_gemma":0.0001500099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":1.163853e-7,"about_ca_topic_score_gemma":1.097917e-8,"domain_scores_codex":[0.9973067,0.0007219743,0.0008189162,0.000280989,0.0006437686,0.0002276526],"domain_scores_gemma":[0.9960485,0.001418457,0.001988317,0.0004348113,0.00003009272,0.00007989261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003162748,0.0002302465,8.657357e-8,0.00188363,0.00006133271,0.00007865562,0.00002962659,0.000007881095,0.978449,0.0027464,0.00003494819,0.01644655],"study_design_scores_gemma":[0.0001181517,0.0002098727,6.631743e-8,0.0008165579,0.0002628094,0.000457543,0.0001244915,0.00000670121,0.9756364,0.01217637,0.01004668,0.0001443874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05478115,0.9321504,0.002970557,0.0006976089,0.002376088,0.001739978,0.0003452288,0.0000562099,0.004882821],"genre_scores_gemma":[0.2596744,0.7398036,0.00004414729,0.0001688164,0.0001863346,0.00001466819,0.000001820961,0.00002833594,0.00007791139],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2048933,"threshold_uncertainty_score":0.557377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3461324877300158,"score_gpt":0.3578124301775053,"score_spread":0.01167994244748954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}