{"id":"W4221134601","doi":"10.1021/acs.molpharmaceut.1c00961","title":"No Dopamine Agonist Modulation of Brain [<sup>18</sup>F]FEOBV Binding in Parkinson’s Disease","year":2022,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Farmer Family Foundation; Parkinson's Foundation; National Institute of Neurological Disorders and Stroke; Weston Brain Institute","keywords":"Dopamine; Dopamine receptor D2; Dopamine transporter; Internal medicine; Vesicular monoamine transporter; Endocrinology; Dopamine agonist; Agonist; Dopamine receptor D3; Binding potential; Parkinson's disease; Dopamine receptor; Levodopa; Medicine; Chemistry; Psychology; Dopaminergic; Monoamine neurotransmitter; Receptor; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002179192,0.0001706554,0.0003595726,0.0002085983,0.0001969749,0.0002622576,0.0001590321,0.0003922201,0.001439423],"category_scores_gemma":[0.0003899492,0.0001915312,0.0001665584,0.0001303672,0.0003343487,0.0001738767,0.0001132743,0.0001651108,0.0001919286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002978554,"about_ca_system_score_gemma":0.0001021554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001948483,"about_ca_topic_score_gemma":0.004019482,"domain_scores_codex":[0.9998724,0.0000339446,0.00001246439,0.00003090349,0.0000296693,0.00002051596],"domain_scores_gemma":[0.9998066,0.00005794454,0.00006409302,0.00001634896,0.00002181025,0.00003319272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01171011,0.0002331864,0.4858097,0.0003594001,0.0004455982,0.004510312,0.000549833,0.0003340428,0.4530972,0.000165346,0.0003270039,0.04245838],"study_design_scores_gemma":[0.00003953532,0.001065708,0.9861109,0.00001032119,0.00007019873,0.003333208,0.000101404,0.000142435,0.008480086,0.00006338129,0.000577864,0.000004833998],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977039,0.001434851,0.00008579084,0.00002010087,0.000002717614,0.000003408115,0.00004986746,0.000002900919,0.0006965221],"genre_scores_gemma":[0.9994849,0.0002213112,0.00005379663,0.00002094526,0.000002481955,0.000002155877,0.00007272426,0.000001459794,0.0001401604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001948483,"threshold_uncertainty_score":0.00481534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03731220298638593,"score_gpt":0.3242196055665183,"score_spread":0.2869074025801324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}