{"id":"W4221134601","doi":"10.1021/acs.molpharmaceut.1c00961","title":"No Dopamine Agonist Modulation of Brain [<sup>18</sup>F]FEOBV Binding in Parkinson’s Disease","year":2022,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Farmer Family Foundation; Parkinson's Foundation; National Institute of Neurological Disorders and Stroke; Weston Brain Institute","keywords":"Dopamine; Dopamine receptor D2; Dopamine transporter; Internal medicine; Vesicular monoamine transporter; Endocrinology; Dopamine agonist; Agonist; Dopamine receptor D3; Binding potential; Parkinson's disease; Dopamine receptor; Levodopa; Medicine; Chemistry; Psychology; Dopaminergic; Monoamine neurotransmitter; Receptor; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001541808,0.0001676612,0.0002451903,0.0001554749,0.00009226349,0.000009456746,0.0001029928,0.00003311128,0.0004891079],"category_scores_gemma":[0.00009019616,0.0001648842,0.0001210629,0.0003560401,0.00005172332,0.00003243651,0.0001359619,0.000269383,0.00001866243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001005081,"about_ca_system_score_gemma":0.00005965097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001860534,"about_ca_topic_score_gemma":5.088453e-7,"domain_scores_codex":[0.998576,0.000158006,0.0002880562,0.0003106517,0.0003966003,0.0002706207],"domain_scores_gemma":[0.9994162,0.00004576774,0.000086164,0.0002385847,0.00003644617,0.0001768168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.004209318,0.006602759,0.5378052,0.0005097196,0.0003770576,0.008965128,0.0003207182,0.06571382,0.3562622,0.0005992879,0.00212621,0.01650859],"study_design_scores_gemma":[0.02944787,0.002345693,0.1639115,0.0001149555,0.0009649844,0.00006678345,0.000198024,0.5224499,0.02612039,0.002296715,0.2509864,0.001096801],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955443,0.0004213799,0.0001480829,0.001812396,0.00007652322,0.0006034163,0.00008141789,0.00003628122,0.001276258],"genre_scores_gemma":[0.9960083,0.00006228568,0.0001953961,0.002905483,0.0000200977,0.0000815338,0.0002071153,0.00003101554,0.0004887294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4567361,"threshold_uncertainty_score":0.6723782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03731220298638593,"score_gpt":0.3242196055665183,"score_spread":0.2869074025801324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}