{"id":"W4221136384","doi":"10.1155/2022/9180267","title":"8‐Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin‐Induced Cardiac Dysfunction","year":2022,"lang":"en","type":"article","venue":"Oxidative Medicine and Cellular Longevity","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Biomedical Research Council; National Medical Research Council; Medical Research Council; Agency for Science, Technology and Research","keywords":"Cardiotoxicity; Doxorubicin; Oxidative stress; DNA damage; DNA glycosylase; DNA repair; Anthracycline; Reactive oxygen species; Pharmacology; Cancer research; Knockout mouse; Biology; Medicine; Internal medicine; Biochemistry; DNA; Gene; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001036297,0.0003789925,0.0007881473,0.0002520299,0.0005900938,0.00001880043,0.0001201113,0.0001226026,0.001284738],"category_scores_gemma":[0.0002289862,0.0003280615,0.0001959846,0.0006809548,0.0002517428,0.0001660782,0.0001432514,0.0006779329,0.00002120243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002827766,"about_ca_system_score_gemma":0.0001295253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003076381,"about_ca_topic_score_gemma":0.00001122368,"domain_scores_codex":[0.9972129,0.0003556197,0.0004437562,0.0007135121,0.0008337031,0.0004404438],"domain_scores_gemma":[0.9986296,0.0001701657,0.0002182921,0.0005071597,0.0001657941,0.0003089308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002770258,0.0002126067,0.003269306,0.000121725,0.0001311086,0.00008496702,0.001563351,0.000004250702,0.9745132,0.0004139755,0.001827344,0.01758109],"study_design_scores_gemma":[0.003918685,0.002230949,0.006695184,0.0001126877,0.0005564038,0.0001387927,0.007681503,0.0001403127,0.9617087,0.0003139529,0.0160764,0.0004264345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862908,0.002858804,0.001038625,0.002701253,0.0006016412,0.0009210857,0.0000300431,0.0001280247,0.005429748],"genre_scores_gemma":[0.9962021,0.0003160567,0.00007537528,0.001096741,0.0006041162,0.0001088667,0.0003688765,0.00004751526,0.001180428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01715466,"threshold_uncertainty_score":0.9999171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02660652635281273,"score_gpt":0.2561483919556735,"score_spread":0.2295418656028608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}