{"id":"W4221137716","doi":"10.21203/rs.3.rs-1420016/v1","title":"Circulating levels of PCSK9, ANGPTL3 and Lp(a) in stage III breast cancers","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Montreal Clinical Research Institute; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Centre Hospitalier Universitaire de Québec; Fondation du cancer du sein du Québec; Université Laval","keywords":"Medicine; PCSK9; Breast cancer; Stage (stratigraphy); Internal medicine; Oncology; Cancer; Cholesterol; Adept; Lipoprotein; LDL receptor; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001251991,0.0002023647,0.0003843615,0.0003436171,0.0001367722,0.0000539121,0.0003507043,0.0002704553,0.0003297453],"category_scores_gemma":[0.0001522303,0.0002305,0.0001242388,0.000265276,0.0002422753,0.000003846102,0.001717956,0.0008463904,7.36487e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002329129,"about_ca_system_score_gemma":0.001380865,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01259281,"about_ca_topic_score_gemma":0.004220603,"domain_scores_codex":[0.9974706,0.0003608621,0.0003454192,0.0007038175,0.0006003442,0.0005189117],"domain_scores_gemma":[0.9988112,0.00004343579,0.0001290148,0.0006479919,0.000230622,0.0001377291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001235063,0.0003680782,0.05719383,0.00785862,0.0005647995,0.00002344431,0.004762299,0.01411507,0.778666,0.001069017,0.01636416,0.1177796],"study_design_scores_gemma":[0.00437988,0.0005709633,0.2601088,0.001097753,0.00004691354,0.00006560187,0.008604564,0.0008301482,0.01169123,0.00048842,0.710743,0.0013727],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803759,0.01282735,0.00005152822,0.0001205642,0.001427257,0.000769588,0.001981843,0.00001001938,0.002435965],"genre_scores_gemma":[0.9922172,0.002910286,0.0000998449,0.00002372917,0.002635158,0.0001918793,0.0002747175,0.00004508886,0.001602039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7669748,"threshold_uncertainty_score":0.9939824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05525406008380829,"score_gpt":0.3848317474241773,"score_spread":0.329577687340369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}