{"id":"W4221138132","doi":"10.1101/2022.03.11.483990","title":"THE STABILIZATAION OF C-MYC BY THE NOVEL CELL CYCLE REGULATOR, SPY1, DECREASES EFFICACY OF BREAST CANCER TREATMENTS","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Windsor Regional Hospital; Western University; University of Windsor","funders":"Ontario Institute for Cancer Research","keywords":"Tamoxifen; Cancer research; Breast cancer; Biology; Cancer; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000498393,0.0004645743,0.0007105033,0.00009852805,0.0002667634,0.00004331522,0.0005705823,0.000211822,0.0004356978],"category_scores_gemma":[0.00005244261,0.000309627,0.0003117713,0.0004645116,0.0002354692,0.00004817936,0.0003777726,0.000461954,0.000001965286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004716862,"about_ca_system_score_gemma":0.001120346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001407261,"about_ca_topic_score_gemma":0.00001467722,"domain_scores_codex":[0.9974366,0.0001177705,0.0006546329,0.000673015,0.0007031289,0.0004148895],"domain_scores_gemma":[0.9965829,0.0001851096,0.0007862168,0.001849536,0.0004017054,0.0001945336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008492,0.001338877,0.003654437,0.0003463186,0.0006522323,0.000006408996,0.00003727093,0.0001577286,0.9914968,0.0007770832,0.0006440484,0.00003959488],"study_design_scores_gemma":[0.00450349,0.0003182928,0.1380347,0.0005707613,0.000923392,1.233355e-7,0.00003884719,0.0001981528,0.8411675,0.000005842319,0.01374743,0.0004915048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851308,0.00932336,0.0001360451,0.0004982864,0.000786566,0.001525143,0.002504425,0.00008134689,0.000014068],"genre_scores_gemma":[0.99579,0.003011309,0.0002962511,0.000126528,0.0002063728,0.000389155,0.000002186559,0.0001310877,0.00004709416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1503293,"threshold_uncertainty_score":0.9999356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136241246811967,"score_gpt":0.2427918961837533,"score_spread":0.2314294837156336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}