{"id":"W4221138132","doi":"10.1101/2022.03.11.483990","title":"THE STABILIZATAION OF C-MYC BY THE NOVEL CELL CYCLE REGULATOR, SPY1, DECREASES EFFICACY OF BREAST CANCER TREATMENTS","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Windsor Regional Hospital; Western University; University of Windsor","funders":"Ontario Institute for Cancer Research","keywords":"Tamoxifen; Cancer research; Breast cancer; Biology; Cancer; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001806915,0.0002241187,0.0003580436,0.0001972691,0.0001427864,0.00026507,0.0002098337,0.0002727284,0.002186656],"category_scores_gemma":[0.00025849,0.0001036593,0.0001891822,0.0001488566,0.0001906148,0.0002334689,0.0001971525,0.0008461,0.000433169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002387515,"about_ca_system_score_gemma":0.0002098591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002550086,"about_ca_topic_score_gemma":0.0004910614,"domain_scores_codex":[0.999856,0.00002060464,0.00001193782,0.0000333368,0.00005142116,0.00002679145],"domain_scores_gemma":[0.9998223,0.00003985097,0.0000462953,0.00002120413,0.00002317485,0.0000472588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002917601,0.00009285827,0.0005224267,0.00008330552,0.00001484057,0.00002361037,0.00001102046,0.000148088,0.9908499,0.00007884944,0.0003289865,0.007554464],"study_design_scores_gemma":[0.00005089921,0.001425684,0.009052935,0.00001630188,0.0000328344,0.0002738418,0.00003675567,0.001633156,0.9821192,0.00006929393,0.005283306,0.000005835487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879689,0.00833249,0.00144809,0.0003137148,0.00007507731,0.0000343912,0.0003772787,0.00009135927,0.001358685],"genre_scores_gemma":[0.9943427,0.002175242,0.0009310393,0.00008350093,0.00001998507,0.00003934709,0.0004004961,0.00002297067,0.001984796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002186656,"threshold_uncertainty_score":0.007315099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136241246811967,"score_gpt":0.2427918961837533,"score_spread":0.2314294837156336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}