{"id":"W4223411743","doi":"10.3389/fmed.2022.869912","title":"MTHFR Gene Polymorphism Association With Psoriatic Arthritis Risk and the Efficacy and Hepatotoxicity of Methotrexate in Psoriasis","year":2022,"lang":"en","type":"article","venue":"Frontiers in Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Shanghai Shenkang Hospital Development Center; Science and Technology Commission of Shanghai Municipality; Dalhousie University; National Natural Science Foundation of China","keywords":"Psoriasis; Methotrexate; Methylenetetrahydrofolate reductase; Psoriatic arthritis; Medicine; Genotype; Dermatology; Internal medicine; Gene; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004557293,0.0002457068,0.0003257997,0.000445064,0.0002812535,0.0002908968,0.0001471902,0.0003028258,0.001263426],"category_scores_gemma":[0.001248603,0.0001718137,0.0004232627,0.0005328793,0.0001736411,0.0001325923,0.0001445252,0.0003593292,0.0001193769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001269781,"about_ca_system_score_gemma":0.0001658747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002355101,"about_ca_topic_score_gemma":0.002292312,"domain_scores_codex":[0.9996907,0.0000925856,0.00004266277,0.00007274519,0.0000617729,0.00003966903],"domain_scores_gemma":[0.99931,0.0001264227,0.0003403369,0.00004867776,0.00004611215,0.0001283865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006291887,0.00005297708,0.9944751,0.00001532093,0.0001334416,0.0001613503,0.00004701941,0.00004210711,0.002070763,0.00001340459,0.00003343706,0.002325944],"study_design_scores_gemma":[0.00001854832,0.0001598251,0.9989725,0.000002752751,0.00006541063,0.0003776682,0.00002288646,0.0001877541,0.0001200295,0.00001970157,0.00005113348,0.000001885513],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994013,0.0003380508,0.00006767395,0.00002494767,0.000002803579,0.000003532482,0.00003500494,0.0000018883,0.0001247593],"genre_scores_gemma":[0.9997843,0.00006773625,0.00004726913,0.000007905997,0.000009132489,0.000001487543,0.00002629624,5.83747e-7,0.00005525399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355101,"threshold_uncertainty_score":0.004682779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007515999397192705,"score_gpt":0.2133707382865088,"score_spread":0.2058547388893162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}