{"id":"W4223420068","doi":"10.1038/s41556-022-00869-0","title":"Aggresome assembly at the centrosome is driven by CP110–CEP97–CEP290 and centriolar satellites","year":2022,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Horizon 2020 Framework Programme; Krembil Foundation; Government of Canada; European Commission; Government of Ontario; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada","keywords":"Aggresome; Cell biology; Centrosome; Centriole; Biology; Microtubule; Microtubule organizing center; Endosome; Intermediate filament; Protein aggregation; Ubiquitin; Chemistry; Cytoskeleton; Cell cycle; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002682442,0.0002574523,0.000219251,0.00003985418,0.0005052575,0.00002594416,0.0004407786,0.0004966293,0.0005504807],"category_scores_gemma":[0.00005243993,0.0001949403,0.0001218151,0.0001248102,0.0001842377,0.000003077014,0.0008357572,0.0006828657,0.00003312353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004411978,"about_ca_system_score_gemma":0.00005181489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008738793,"about_ca_topic_score_gemma":0.00000817981,"domain_scores_codex":[0.9981571,0.0003441135,0.0002105937,0.0006403869,0.0001417768,0.0005059561],"domain_scores_gemma":[0.9991628,0.00006734402,0.0001523318,0.0004543678,0.00004719068,0.0001159863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001070446,0.00005234541,0.006925015,0.00001362948,0.00004380312,0.000005275599,0.00009179538,0.000003557758,0.9551744,0.000106956,0.03536351,0.00211264],"study_design_scores_gemma":[0.0003694366,0.0002420471,0.0001898054,0.00000146946,0.00001229666,0.00002302529,0.00003575043,0.00001116936,0.4527448,0.00009758014,0.5461168,0.0001557788],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8983977,0.09612448,0.000008791309,0.00186019,0.0004521918,0.0003893114,0.0008584766,0.0000229901,0.001885894],"genre_scores_gemma":[0.985032,0.003457951,0.000104252,0.005685889,0.0002648512,0.00006408969,0.001388115,0.00003412562,0.003968685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5107533,"threshold_uncertainty_score":0.7949436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004205439152433636,"score_gpt":0.2199445938237644,"score_spread":0.2157391546713308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}