{"id":"W4223420068","doi":"10.1038/s41556-022-00869-0","title":"Aggresome assembly at the centrosome is driven by CP110–CEP97–CEP290 and centriolar satellites","year":2022,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Horizon 2020 Framework Programme; Krembil Foundation; Government of Canada; European Commission; Government of Ontario; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada","keywords":"Aggresome; Cell biology; Centrosome; Centriole; Biology; Microtubule; Microtubule organizing center; Endosome; Intermediate filament; Protein aggregation; Ubiquitin; Chemistry; Cytoskeleton; Cell cycle; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071877,0.0002357051,0.0001683362,0.0001713046,0.0001977297,0.0003294151,0.000155453,0.000173074,0.0005601723],"category_scores_gemma":[0.0001145889,0.0001454294,0.0001456019,0.0001524923,0.0002514372,0.0001381653,0.0002031674,0.000331661,0.0002966758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006067274,"about_ca_system_score_gemma":0.0002224883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077777,"about_ca_topic_score_gemma":0.002000351,"domain_scores_codex":[0.9998945,0.00001338294,0.00001359177,0.0000195512,0.00004305876,0.00001590862],"domain_scores_gemma":[0.9998436,0.00002630949,0.00005423994,0.00001962794,0.00001611592,0.00004014186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003520331,0.000005265935,0.0001841188,0.000007557779,0.000001988601,0.00009569663,0.000004785242,0.00004476327,0.9992958,0.00008169855,0.00001496933,0.000228073],"study_design_scores_gemma":[0.000006327572,0.00003648587,0.005456038,0.000001645054,0.000003358068,0.0003799075,0.00001251079,0.001096909,0.9922071,0.00004118406,0.0007565035,0.000002068489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972058,0.0002804213,0.00170425,0.00004275883,0.000006963625,0.000009988402,0.0002322374,0.00003288423,0.0004846012],"genre_scores_gemma":[0.9966126,0.0002530551,0.001530414,0.00002119815,0.000003525553,0.00001159525,0.0005136233,0.00001782651,0.001036153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001077777,"threshold_uncertainty_score":0.004402161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004205439152433636,"score_gpt":0.2199445938237644,"score_spread":0.2157391546713308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}