{"id":"W4223429787","doi":"10.1002/bies.202200008","title":"Multifaceted targeted protein degradation systems for different cellular compartments","year":2022,"lang":"en","type":"review","venue":"BioEssays","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Biology; Protein degradation; Cell biology; Autophagy; Transcription factor; Proteasome; Ubiquitin; Proteostasis; Computational biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002394503,0.0004947477,0.0008469216,0.0001242159,0.0002260141,0.00007143348,0.0003900807,0.0003721287,0.00008631413],"category_scores_gemma":[0.0001049815,0.0004090689,0.0004681355,0.0001394937,0.00004262949,0.000004259859,0.0001783476,0.0001799009,0.00001901566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001188411,"about_ca_system_score_gemma":0.0001487807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001453043,"about_ca_topic_score_gemma":0.000002246776,"domain_scores_codex":[0.9977379,0.0003300775,0.0006399307,0.0006832645,0.0002693963,0.0003393664],"domain_scores_gemma":[0.9987013,0.00002407335,0.0005168761,0.0005810643,0.00006221344,0.0001144821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001933962,0.001314904,0.00001742059,0.03770063,0.001845934,0.00001163699,0.00003654675,0.00001992775,0.0548801,0.00109804,0.04977573,0.8531057],"study_design_scores_gemma":[0.0004894041,0.0002303724,3.972767e-7,0.0006165,0.0001685451,0.000003268202,0.00001806759,0.00008557055,0.008059273,0.000003827688,0.9898607,0.00046403],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003075915,0.9904168,0.002235736,0.00000840161,0.0008818399,0.005251379,0.0007135412,0.00005036752,0.0001343212],"genre_scores_gemma":[0.0004131039,0.9619338,0.0002498746,0.00001655009,0.0004282576,0.005346875,0.0271355,0.0001104071,0.004365654],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.940085,"threshold_uncertainty_score":0.9998361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06242777414752321,"score_gpt":0.3073077077529889,"score_spread":0.2448799336054657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}