{"id":"W4223429787","doi":"10.1002/bies.202200008","title":"Multifaceted targeted protein degradation systems for different cellular compartments","year":2022,"lang":"en","type":"review","venue":"BioEssays","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Biology; Protein degradation; Cell biology; Autophagy; Transcription factor; Proteasome; Ubiquitin; Proteostasis; Computational biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007658953,0.001481852,0.001294057,0.00312611,0.0003795403,0.00122663,0.001218727,0.00135198,0.002917098],"category_scores_gemma":[0.0003618984,0.0005219225,0.000720055,0.002082667,0.0008606715,0.002106872,0.001061026,0.00247079,0.003342353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001232646,"about_ca_system_score_gemma":0.0008537431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006661491,"about_ca_topic_score_gemma":0.001247982,"domain_scores_codex":[0.9997405,0.00003278311,0.00003374569,0.00006185794,0.00009819794,0.00003284317],"domain_scores_gemma":[0.9998399,0.00005940464,0.00003046377,0.00001211359,0.00003938303,0.00001865055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009556355,0.0001029709,0.0001273642,0.01677074,0.0001134972,0.0003050547,0.00008122796,0.0007116748,0.02082136,0.02440024,0.02089912,0.9155713],"study_design_scores_gemma":[0.00001266578,0.00007971448,0.0002222489,0.0008808249,0.00005856052,0.001063802,0.00001933989,0.0001003973,0.004501483,0.002309863,0.9907308,0.00002021035],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002690859,0.9949279,0.001462296,0.0002615058,0.0002260726,0.00002187267,0.00004379045,0.00004129478,0.00274631],"genre_scores_gemma":[0.001656583,0.993476,0.001790235,0.0003446905,0.0001150847,0.00004167036,0.0001039191,0.000007488018,0.002464264],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00312611,"threshold_uncertainty_score":0.009758711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06242777414752321,"score_gpt":0.3073077077529889,"score_spread":0.2448799336054657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}