{"id":"W4223430503","doi":"10.1158/2159-8290.cd-21-0521","title":"PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon","year":2022,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; National Institute of General Medical Sciences; Foundation Medicine; Marie-Josée and Henry R. Kravis Center for Molecular Oncology; Novartis Pharma; Ipsen; Genentech; Institut Gustave-Roussy; European Society for Medical Oncology; Basilea Pharmaceutica; Astellas Pharma; Eisai; Agence Nationale de la Recherche; Bayer HealthCare; Pfizer; Incyte; Boston Pharmaceuticals; Eisai Canada; BeiGene; Chugai Pharmaceutical; Swim Across America; Relay Therapeutics; Seagen; Agios Pharmaceuticals; National Institutes of Health; Mylan; Loxo Oncology; Astex Pharmaceuticals; Oryzon Genomics; Covis Pharma; Les Laboratories Pierre Fabre; Daiichi Sankyo Europe; National Cancer Institute; Servier; Gilead Sciences; Merck KGaA; Exelixis; Sanofi; Institut Servier; Memorial Sloan-Kettering Cancer Center; GlaxoSmithKline; Amgen; Celgene; Institut National Du Cancer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Proofreading; Blockade; Biomarker; Cancer; Mutation; Polymerase; Gene duplication","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001973957,0.000170155,0.0002938751,0.0001067233,0.00009866162,0.0002302519,0.000105276,0.000208645,0.0006116708],"category_scores_gemma":[0.0002006199,0.00005179901,0.0000901835,0.0001006418,0.0001374779,0.0001322519,0.000104759,0.0003964582,0.0001223684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000258239,"about_ca_system_score_gemma":0.0001458889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000178465,"about_ca_topic_score_gemma":0.0004308043,"domain_scores_codex":[0.9999384,0.00001559247,0.000005520948,0.00001105392,0.00001006315,0.00001942866],"domain_scores_gemma":[0.9999059,0.00003006703,0.00002461861,0.000006467101,0.000007018291,0.00002574748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01399718,0.001593637,0.03318174,0.0004050786,0.0001488056,0.001543722,0.0001090298,0.001809274,0.7891471,0.0005656941,0.002321845,0.1551768],"study_design_scores_gemma":[0.002435978,0.05490661,0.1404715,0.00007026894,0.0002499873,0.01129466,0.0001444633,0.008130068,0.7609829,0.0008353553,0.02045192,0.00002625678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958988,0.00247852,0.0003322104,0.0001395412,0.00002980646,0.00002755761,0.00007003741,0.00002881059,0.0009947933],"genre_scores_gemma":[0.9986361,0.0004929466,0.0003117336,0.00004491796,0.00001291837,0.00001101335,0.00009056733,0.000003970214,0.0003958126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006116708,"threshold_uncertainty_score":0.002046227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291903537555423,"score_gpt":0.277357631919511,"score_spread":0.2644385965439567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}