{"id":"W4223430503","doi":"10.1158/2159-8290.cd-21-0521","title":"PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon","year":2022,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; National Institute of General Medical Sciences; Foundation Medicine; Marie-Josée and Henry R. Kravis Center for Molecular Oncology; Novartis Pharma; Ipsen; Genentech; Institut Gustave-Roussy; European Society for Medical Oncology; Basilea Pharmaceutica; Astellas Pharma; Eisai; Agence Nationale de la Recherche; Bayer HealthCare; Pfizer; Incyte; Boston Pharmaceuticals; Eisai Canada; BeiGene; Chugai Pharmaceutical; Swim Across America; Relay Therapeutics; Seagen; Agios Pharmaceuticals; National Institutes of Health; Mylan; Loxo Oncology; Astex Pharmaceuticals; Oryzon Genomics; Covis Pharma; Les Laboratories Pierre Fabre; Daiichi Sankyo Europe; National Cancer Institute; Servier; Gilead Sciences; Merck KGaA; Exelixis; Sanofi; Institut Servier; Memorial Sloan-Kettering Cancer Center; GlaxoSmithKline; Amgen; Celgene; Institut National Du Cancer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Proofreading; Blockade; Biomarker; Cancer; Mutation; Polymerase; Gene duplication","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001227616,0.0001962078,0.0003715651,0.000242875,0.00005602563,0.00001800976,0.0001371096,0.0000414242,0.0006543751],"category_scores_gemma":[0.00002768228,0.0001762892,0.00005838947,0.0006735011,0.00008118278,0.0001039396,0.0001261201,0.0004704859,0.000004609909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001120005,"about_ca_system_score_gemma":0.000854041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001678579,"about_ca_topic_score_gemma":0.002776169,"domain_scores_codex":[0.9984102,0.00006451217,0.0002609947,0.0004241927,0.0004120173,0.0004281184],"domain_scores_gemma":[0.9994527,0.00005098865,0.00007728354,0.0003035561,0.00001672663,0.00009874746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002499314,0.000334072,0.9493214,0.0001413933,0.00004100785,0.0007838251,0.001152421,0.01410253,0.02929578,0.00002918728,0.0008545087,0.001444509],"study_design_scores_gemma":[0.007936694,0.002092506,0.8783958,0.0006778484,0.00009971757,0.000182739,0.001921622,0.0005453353,0.1049729,0.0001709294,0.002274087,0.0007298067],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937786,0.003086566,0.00000762963,0.0005803491,0.0004026887,0.0005188524,0.00004766256,0.00002627002,0.001551344],"genre_scores_gemma":[0.9968287,0.00007844844,0.0000534754,0.001111662,0.00008720501,0.0006928488,0.00001770387,0.00004562709,0.001084363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07567716,"threshold_uncertainty_score":0.7188866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291903537555423,"score_gpt":0.277357631919511,"score_spread":0.2644385965439567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}