{"id":"W4223433370","doi":"10.1016/j.cmet.2022.03.008","title":"Ketones regulate endothelial homeostasis","year":2022,"lang":"en","type":"letter","venue":"Cell Metabolism","topic":"Diet and metabolism studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Western University; St. Michael's Hospital; University of Alberta","funders":"Canadian Institutes of Health Research; Novartis; AstraZeneca; Bayer; Boehringer Ingelheim; Eli Lilly and Company","keywords":"Ketone bodies; Heart failure; Endothelial stem cell; Ketone; Homeostasis; Ketogenic diet; Cell biology; Biology; Cell growth; Cell; Internal medicine; Chemistry; Endocrinology; Medicine; Biochemistry; Neuroscience; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002007378,0.0008869506,0.00142632,0.0006378906,0.003273143,0.003374275,0.001156896,0.02922989,0.003826086],"category_scores_gemma":[0.008791341,0.0004875624,0.0009022309,0.0004864515,0.002950413,0.002527752,0.001771312,0.03129632,0.002660715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002886279,"about_ca_system_score_gemma":0.001689514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003021794,"about_ca_topic_score_gemma":0.005019954,"domain_scores_codex":[0.9986979,0.0004921563,0.0001315967,0.0001494833,0.0003651479,0.000163756],"domain_scores_gemma":[0.9967929,0.001807018,0.0002833855,0.0001671434,0.0004168103,0.0005326724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000422042,0.0001037853,0.0014245,0.0001631114,0.00008770582,0.005929661,0.0002117357,0.00008838149,0.001078996,0.00796998,0.9529672,0.02955296],"study_design_scores_gemma":[0.0005447197,0.0002233365,0.003082373,0.0004661573,0.0001144735,0.003484013,0.0005184084,0.0004484808,0.001158009,0.03240345,0.9574735,0.00008308682],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001047524,0.009725174,0.00010079,0.9489031,0.03646636,0.000009307504,0.00003540385,0.00002119127,0.003691138],"genre_scores_gemma":[0.01409037,0.007366673,0.0002556632,0.8477288,0.1235724,0.00004344822,0.00002771526,0.00002166317,0.006893303],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02922989,"threshold_uncertainty_score":0.02094156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998628777360073,"score_gpt":0.2464785179876582,"score_spread":0.2264922302140575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}