{"id":"W4223433370","doi":"10.1016/j.cmet.2022.03.008","title":"Ketones regulate endothelial homeostasis","year":2022,"lang":"en","type":"letter","venue":"Cell Metabolism","topic":"Diet and metabolism studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Western University; St. Michael's Hospital; University of Alberta","funders":"Canadian Institutes of Health Research; Novartis; AstraZeneca; Bayer; Boehringer Ingelheim; Eli Lilly and Company","keywords":"Ketone bodies; Heart failure; Endothelial stem cell; Ketone; Homeostasis; Ketogenic diet; Cell biology; Biology; Cell growth; Cell; Internal medicine; Chemistry; Endocrinology; Medicine; Biochemistry; Neuroscience; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003405547,0.0008357971,0.002063151,0.0004233338,0.000329998,0.0000625916,0.0004535513,0.0006568321,0.005477039],"category_scores_gemma":[0.00009927447,0.0007217631,0.0008922255,0.0004588694,0.0002278032,0.00009213023,0.0004571091,0.002826367,0.0005504725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006973739,"about_ca_system_score_gemma":0.0002507133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007661,"about_ca_topic_score_gemma":0.000001165761,"domain_scores_codex":[0.9959115,0.0002129837,0.0006719292,0.0009811559,0.001202063,0.001020397],"domain_scores_gemma":[0.9979178,0.0001352871,0.0003761692,0.001215877,0.0001744054,0.0001805101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001261056,0.00009644426,0.00003877143,0.0004720542,0.0004101759,0.001051296,0.0004637811,3.85753e-7,0.001016949,0.00008357773,0.9889935,0.007246978],"study_design_scores_gemma":[0.001889609,0.00007732068,0.001854916,0.000040524,0.002535934,0.00004512472,0.0001163276,9.217366e-7,0.002006362,0.0002693631,0.9904898,0.0006737681],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.008940515,0.1427509,0.0000107357,0.6546333,0.02218512,0.002003604,0.001196521,0.0007049092,0.1675744],"genre_scores_gemma":[0.001111011,0.01782216,0.0008540877,0.6818956,0.02842721,0.0004172088,0.00112842,0.0003992583,0.267945],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1249287,"threshold_uncertainty_score":0.9995233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998628777360073,"score_gpt":0.2464785179876582,"score_spread":0.2264922302140575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}