{"id":"W4223434313","doi":"10.1038/s41392-022-00927-x","title":"LSD1 is required for euchromatic origin firing and replication timing","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Origin recognition complex; Euchromatin; Chromatin; Origin of replication; Pre-replication complex; Control of chromosome duplication; Biology; DNA replication; Replication timing; Licensing factor; Genetics; Eukaryotic DNA replication; SeqA protein domain; DNA replication factor CDT1; Cell biology; DNA; Heterochromatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082022,0.0001765235,0.0001771543,0.0001367086,0.0001865667,0.0003236614,0.0001951768,0.0002300717,0.001057284],"category_scores_gemma":[0.0001675562,0.0001445496,0.0001547188,0.00008493576,0.0002440396,0.0001522098,0.0002347696,0.0002195829,0.0005995993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003518479,"about_ca_system_score_gemma":0.000298069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005627754,"about_ca_topic_score_gemma":0.0007217681,"domain_scores_codex":[0.9999081,0.0000121043,0.0000101392,0.00003169322,0.00001780623,0.00002024391],"domain_scores_gemma":[0.9998602,0.00001759532,0.00005862691,0.00001864349,0.00001068826,0.00003426154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001196482,0.000007390442,0.0008354877,0.00003650788,0.000003470728,0.0000816827,0.00001095243,0.00006901081,0.9967494,0.0001536079,0.00004176474,0.00189114],"study_design_scores_gemma":[0.00001170609,0.00009202265,0.01937123,0.000006798768,0.00001122113,0.0007278636,0.00003052074,0.0007127216,0.975266,0.0002203882,0.003541127,0.000008345953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853598,0.003560774,0.008007519,0.0001532277,0.00003015458,0.00001348273,0.0007675039,0.000307665,0.001799841],"genre_scores_gemma":[0.9970319,0.0003702773,0.0009941439,0.0000145279,0.000003152405,0.00000530383,0.000285373,0.00001239243,0.001282906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001057284,"threshold_uncertainty_score":0.003536999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04148904896988815,"score_gpt":0.2963178802413296,"score_spread":0.2548288312714415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}