{"id":"W4223434313","doi":"10.1038/s41392-022-00927-x","title":"LSD1 is required for euchromatic origin firing and replication timing","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Origin recognition complex; Euchromatin; Chromatin; Origin of replication; Pre-replication complex; Control of chromosome duplication; Biology; DNA replication; Replication timing; Licensing factor; Genetics; Eukaryotic DNA replication; SeqA protein domain; DNA replication factor CDT1; Cell biology; DNA; Heterochromatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002406242,0.00008538683,0.00007913193,0.00003901014,0.0002739539,0.00001863904,0.00003991734,0.00004280895,0.00008633642],"category_scores_gemma":[0.000005994616,0.00008911798,0.00003873435,0.00006341613,0.00002806155,0.000005479983,0.000009450307,0.00004670601,2.323514e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008252849,"about_ca_system_score_gemma":0.00001715134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005636836,"about_ca_topic_score_gemma":0.000001022332,"domain_scores_codex":[0.9993392,0.00004841078,0.0001375264,0.0002935095,0.00007611584,0.0001052127],"domain_scores_gemma":[0.9997306,0.00001091817,0.00005328135,0.0001363549,0.00003134918,0.00003745309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001234591,0.00002319268,0.0002669633,0.00001311815,0.00002966253,1.00302e-7,0.0003247432,0.000102999,0.95908,0.00006230592,0.00006198945,0.03991141],"study_design_scores_gemma":[0.001145243,0.0006297889,0.001173413,0.000003998867,0.0000140335,0.000006363908,0.0001434411,0.00137567,0.9195654,0.002433834,0.07334,0.0001688417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772171,0.007199097,0.01462524,0.0004631241,0.00009447277,0.0003121855,0.00002636137,0.00001436687,0.00004802909],"genre_scores_gemma":[0.9967977,0.001159165,0.001321612,0.0001729994,0.0001136922,0.0001014131,0.0001425863,0.00001654945,0.0001742882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07327801,"threshold_uncertainty_score":0.3634126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04148904896988815,"score_gpt":0.2963178802413296,"score_spread":0.2548288312714415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}