{"id":"W4223439574","doi":"10.1016/s0140-6736(22)00456-1","title":"Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study","year":2022,"lang":"en","type":"article","venue":"The Lancet","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":311,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute","funders":"Novo Nordisk Fonden; Bayer","keywords":"Apixaban; Atrial fibrillation; Medicine; Double blind; Internal medicine; Cardiology; Gastroenterology; Surgery; Warfarin; Rivaroxaban; Pathology; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005448699,0.000274475,0.000827167,0.0001273006,0.0003933241,0.00004674006,0.0002717114,0.00004632119,0.0001676307],"category_scores_gemma":[0.00002583509,0.0001517975,0.0001516952,0.0006681347,0.0001236336,0.0001388577,0.0001244462,0.0003110368,0.000003040197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001859377,"about_ca_system_score_gemma":0.0001488055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003997708,"about_ca_topic_score_gemma":0.0004703943,"domain_scores_codex":[0.9975429,0.0002720307,0.0005931415,0.0003503612,0.0008524634,0.0003891337],"domain_scores_gemma":[0.9985193,0.0001783488,0.0004670655,0.0006410711,0.0001057828,0.00008843873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3765147,0.0003986293,0.6147534,0.00002651991,0.0002114984,0.000003594436,0.005502696,0.001820067,0.00002878292,0.00003604824,0.0001231821,0.000580859],"study_design_scores_gemma":[0.5788226,0.001079592,0.4151449,0.0001041863,0.0002726608,0.000004760052,0.00212376,0.0009020094,0.0001766491,0.00000638358,0.001157103,0.0002054412],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933653,0.0001023315,0.00001322952,0.0005649244,0.0003208632,0.005179848,0.0001341362,0.00005454399,0.0002648034],"genre_scores_gemma":[0.9988533,0.000003517307,0.00005400398,0.00005155272,0.0005600571,0.00003862609,0.0002253334,0.00003973173,0.0001739138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2023079,"threshold_uncertainty_score":0.6190122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05554178429844667,"score_gpt":0.3095016250490084,"score_spread":0.2539598407505617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}