{"id":"W4223439574","doi":"10.1016/s0140-6736(22)00456-1","title":"Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study","year":2022,"lang":"en","type":"article","venue":"The Lancet","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":311,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute","funders":"Novo Nordisk Fonden; Bayer","keywords":"Apixaban; Atrial fibrillation; Medicine; Double blind; Internal medicine; Cardiology; Gastroenterology; Surgery; Warfarin; Rivaroxaban; Pathology; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001679829,0.00221888,0.003932636,0.0004262942,0.0004074171,0.001471662,0.001008692,0.001914979,0.006378963],"category_scores_gemma":[0.002221175,0.001019392,0.002230832,0.0004631421,0.001362855,0.001483476,0.0004624638,0.003596954,0.0008662014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000676388,"about_ca_system_score_gemma":0.001028733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008476155,"about_ca_topic_score_gemma":0.001302351,"domain_scores_codex":[0.9993599,0.0003452303,0.00004060434,0.0001075206,0.00004639629,0.0001003428],"domain_scores_gemma":[0.9988545,0.0003978524,0.0002555553,0.0001058033,0.00007305196,0.0003131433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9874896,0.002780125,0.0002666473,0.0004307831,0.0006764519,0.00002153892,0.00003320513,0.0001293422,0.001662483,0.00005353349,0.0002625657,0.006193605],"study_design_scores_gemma":[0.9528938,0.04493692,0.001028746,0.00001669119,0.000401605,0.00002322431,0.00001744142,0.0001827089,0.0001878377,0.00008669875,0.0002116273,0.00001264222],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909177,0.00445657,0.0005092765,0.0005268865,0.0005274176,0.001276577,0.0004619117,0.00008932272,0.001234257],"genre_scores_gemma":[0.9888686,0.00353519,0.001291915,0.0009429269,0.0005562769,0.001712488,0.0005116406,0.00003046021,0.002550388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006378963,"threshold_uncertainty_score":0.02133971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05554178429844667,"score_gpt":0.3095016250490084,"score_spread":0.2539598407505617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}