{"id":"W4223440727","doi":"10.1111/cas.15367","title":"Altered gene expression due to aberrant DNA methylation correlates with responsiveness to anti‐EGFR antibody treatment","year":2022,"lang":"en","type":"article","venue":"Cancer Science","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"DNA methylation; Cetuximab; Methylation; Carcinogenesis; Biology; CpG site; Promoter; Cancer research; Gene; Gene expression; Molecular biology; Colorectal cancer; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002815484,0.0001637806,0.0001570524,0.0001674193,0.0004756563,0.00004194202,0.0003033706,0.00004211502,0.00005745417],"category_scores_gemma":[0.00003010843,0.0001413383,0.00003792105,0.0008842235,0.00009603331,0.00001581622,0.0002187131,0.00005551637,0.000005673659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004466366,"about_ca_system_score_gemma":0.0006196115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001030881,"about_ca_topic_score_gemma":0.00006319279,"domain_scores_codex":[0.9983451,0.0000751453,0.0001682246,0.0007044501,0.00038709,0.0003200249],"domain_scores_gemma":[0.9991026,0.00001056448,0.00009316299,0.0004665859,0.0001520501,0.0001750677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000403948,0.00002862447,0.0009575732,0.000002402738,0.0000109783,0.000003696599,0.0003086546,0.1353431,0.8544328,0.000005120535,0.0001986378,0.008304518],"study_design_scores_gemma":[0.0004793183,0.0009182699,0.0265657,0.00002217348,0.00001636413,0.00002847329,0.00009514593,0.0007280946,0.9601523,0.000006924018,0.01076651,0.0002207541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900941,0.0006582603,0.007349362,0.0005801191,0.0006227289,0.0005603067,0.00004959282,0.00001881495,0.00006671713],"genre_scores_gemma":[0.9978099,0.00005663924,0.00103264,0.0002057076,0.0001526928,0.0002697658,0.00007421632,0.0000201498,0.0003782689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.134615,"threshold_uncertainty_score":0.5763608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275516908619481,"score_gpt":0.2989709868294412,"score_spread":0.2862158177432464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}