{"id":"W4223443704","doi":"10.1128/jvi.00389-22","title":"Single Immunization with Recombinant ACAM2000 Vaccinia Viruses Expressing the Spike and the Nucleocapsid Proteins Protects Hamsters against SARS-CoV-2-Caused Clinical Disease","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada; Canadian Food Inspection Agency; University of Manitoba; Public Health Agency of Canada","funders":"Health Canada; Government of Canada; Public Health Agency of Canada","keywords":"Virology; Biology; Vaccinia; Virus; Immunity; Immunization; Immune system; Antibody; Vaccination; Antigen; Hamster; Immunology; Recombinant DNA; Gene; Genetics; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002364769,0.0003089996,0.0003483642,0.0001698769,0.00009455183,0.0001859121,0.0001575355,0.0002915093,0.0005762038],"category_scores_gemma":[0.0001402629,0.00009698953,0.0002412363,0.00007995812,0.0001697184,0.0001826191,0.0001275797,0.0004090181,0.0001210327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002087738,"about_ca_system_score_gemma":0.0002489717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003371417,"about_ca_topic_score_gemma":0.0004941134,"domain_scores_codex":[0.9998924,0.00001394012,0.000009249867,0.00002695689,0.00002231657,0.00003517639],"domain_scores_gemma":[0.9999133,0.0000121916,0.00002380344,0.00001147819,0.0000107473,0.00002836396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002568897,0.0001736869,0.0004269062,0.00001897329,0.000007736983,0.00001443467,0.0000129471,0.00005946802,0.9978435,0.00004140999,0.00001610476,0.001127927],"study_design_scores_gemma":[0.0001050669,0.008981695,0.008269805,0.00001150754,0.00003622802,0.0001402663,0.00003120181,0.001322797,0.9800729,0.00004708812,0.0009764259,0.000005031526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990566,0.0001671381,0.0004828401,0.00001433309,0.00001315636,0.00001831275,0.00003980101,0.00001362636,0.0001942543],"genre_scores_gemma":[0.9974988,0.000187392,0.001092433,0.00002648313,0.00001271003,0.00001883461,0.0002455741,0.000006619312,0.0009110761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005762038,"threshold_uncertainty_score":0.001927555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06302061319037797,"score_gpt":0.3534557888790484,"score_spread":0.2904351756886704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}