{"id":"W4223448876","doi":"10.1186/s13046-022-02331-3","title":"PPFIA4 promotes castration-resistant prostate cancer by enhancing mitochondrial metabolism through MTHFD2","year":2022,"lang":"en","type":"article","venue":"Journal of Experimental & Clinical Cancer Research","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Key Research and Development Program of China; Shandong Academy of Medical Sciences; National Natural Science Foundation of China; Shandong University","keywords":"Prostate cancer; Cancer research; Enzalutamide; Biology; Mitochondrion; Apoptosis; Androgen receptor; Cancer; Cell biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00166375,0.0002059622,0.0004124268,0.00006544212,0.0004479154,0.00009219747,0.000624877,0.0001043234,0.0007929089],"category_scores_gemma":[0.0004179982,0.0001827363,0.0002735532,0.0002673452,0.0003168482,0.00003890848,0.0005636784,0.0009474017,0.00000329567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349913,"about_ca_system_score_gemma":0.00120413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008940917,"about_ca_topic_score_gemma":0.0001118363,"domain_scores_codex":[0.9958445,0.0007961449,0.001089698,0.0004805511,0.001248459,0.0005406566],"domain_scores_gemma":[0.9984072,0.000118706,0.0004884853,0.0003321081,0.0004217049,0.0002317524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003206942,0.0005281877,0.000286857,0.00001341981,0.0001625388,0.00003320795,0.000204583,0.00003864106,0.9423142,0.00008755754,0.05224903,0.0008748147],"study_design_scores_gemma":[0.001992099,0.002187618,0.0001491953,0.00003738278,0.00002190759,0.00002102378,0.0006245137,0.000003889142,0.8650656,0.00008832367,0.1296323,0.0001761246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7996842,0.1960992,0.00003403018,0.001546821,0.001409085,0.0006874978,0.0004547322,0.0000062646,0.00007819135],"genre_scores_gemma":[0.9926983,0.002653859,0.001034794,0.0003569811,0.002014575,0.0005213995,0.00006136461,0.00005038352,0.0006083667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1934453,"threshold_uncertainty_score":0.8681796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08151686311396482,"score_gpt":0.477385479906476,"score_spread":0.3958686167925112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}