{"id":"W4223457247","doi":"10.3390/cancers14071630","title":"5-Azacytidine Downregulates the Proliferation and Migration of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Targeting miR-139-5p/ROCK2 Pathway","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; MaRS","funders":"Javna Agencija za Raziskovalno Dejavnost RS","keywords":"Cyclin D1; Cancer research; Cyclin E1; ROCK2; Downregulation and upregulation; Cell growth; Cell cycle; Biology; Chemistry; Cell biology; Cell; RHOA; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002151122,0.0000792668,0.00009280258,0.00003619721,0.00007046083,0.00001062332,0.00004877338,0.00004342617,0.000004459123],"category_scores_gemma":[0.00001561517,0.00007180752,0.00001670662,0.00008922148,0.00003859575,0.000004171011,0.00005382183,0.00006417957,3.71832e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006905029,"about_ca_system_score_gemma":0.00007691392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004565546,"about_ca_topic_score_gemma":0.0002174617,"domain_scores_codex":[0.9993438,0.00008823974,0.0001810162,0.0001975484,0.00008176364,0.0001076501],"domain_scores_gemma":[0.9997663,0.00001293926,0.00008109835,0.00009473074,0.00002280224,0.00002215592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007946329,0.00001452276,0.02729649,0.00001758807,0.000003590196,5.778193e-7,0.0003113181,0.001190707,0.9705492,0.000003200002,0.0001179456,0.0004154416],"study_design_scores_gemma":[0.0006114444,0.00008782027,0.001689091,0.000003773858,0.000003804622,4.78932e-7,0.0002840836,0.009841702,0.9834388,0.00003619698,0.003921588,0.00008120907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914061,0.008061012,0.00006174302,0.0001009785,0.0000412005,0.0002562746,0.00004718589,0.000001711989,0.00002373308],"genre_scores_gemma":[0.9991089,0.0005133585,0.00008130892,0.00004501681,0.00002976849,0.0000605233,0.0001042039,0.000008799785,0.00004818408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0256074,"threshold_uncertainty_score":0.2928225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005882041750803162,"score_gpt":0.2012938497998893,"score_spread":0.1954118080490861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}