{"id":"W4223457247","doi":"10.3390/cancers14071630","title":"5-Azacytidine Downregulates the Proliferation and Migration of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Targeting miR-139-5p/ROCK2 Pathway","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; MaRS","funders":"Javna Agencija za Raziskovalno Dejavnost RS","keywords":"Cyclin D1; Cancer research; Cyclin E1; ROCK2; Downregulation and upregulation; Cell growth; Cell cycle; Biology; Chemistry; Cell biology; Cell; RHOA; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137564,0.000298684,0.0002238477,0.0002692403,0.0001626871,0.0001735422,0.0001369838,0.0001885753,0.001506697],"category_scores_gemma":[0.00007456362,0.0001114682,0.0002187704,0.0001411439,0.0001953926,0.0001101238,0.0001004724,0.0005904425,0.0003126057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605325,"about_ca_system_score_gemma":0.00025054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069229,"about_ca_topic_score_gemma":0.002225028,"domain_scores_codex":[0.9998823,0.00001648193,0.00001251989,0.00002184301,0.00004313081,0.00002370125],"domain_scores_gemma":[0.9999614,0.000007783216,0.000009886407,0.000005725067,0.00000607579,0.000009196532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001177535,0.00004304207,0.0001396574,0.00005218805,0.000008308725,0.00003212953,0.00001142584,0.00004082349,0.9975861,0.0000599956,0.00008407985,0.001824524],"study_design_scores_gemma":[0.00002203126,0.000422208,0.002943977,0.000006283316,0.00002754488,0.0001048659,0.00001481548,0.0005658419,0.9928966,0.00002505699,0.002967971,0.000002834101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979596,0.01087038,0.0031247,0.0003362956,0.0001453953,0.00004888093,0.0005076476,0.0002495029,0.00512114],"genre_scores_gemma":[0.9890825,0.003724955,0.002084424,0.00008891902,0.00003138937,0.00005787351,0.0005786805,0.00001790938,0.004333493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001506697,"threshold_uncertainty_score":0.005040348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005882041750803162,"score_gpt":0.2012938497998893,"score_spread":0.1954118080490861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}