{"id":"W4223463116","doi":"10.1038/s41598-022-09804-7","title":"Laminin matrix regulates beta-cell FGFR5 expression to enhance glucose-stimulated metabolism","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Laminin; Carbohydrate metabolism; BETA (programming language); Cell biology; Cell metabolism; Metabolism; Matrix (chemical analysis); Extracellular matrix; Computational biology; Chemistry; Biology; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009719721,0.0002629436,0.0001161269,0.0001273398,0.00007975123,0.0002628779,0.0001029248,0.00014764,0.001522923],"category_scores_gemma":[0.00006995731,0.00007542034,0.0001597904,0.0001083258,0.0001017317,0.0001126908,0.0001383654,0.000244292,0.0003486531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002976669,"about_ca_system_score_gemma":0.0001095518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000846529,"about_ca_topic_score_gemma":0.00129375,"domain_scores_codex":[0.9998939,0.00002408248,0.000008848549,0.00001502794,0.00002820018,0.00002991605],"domain_scores_gemma":[0.9999394,0.00001086641,0.00001961957,0.000005313776,0.000008485423,0.00001624231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003913903,0.000005416633,0.00007273242,0.00001467754,0.000001271317,0.00001939081,0.000004324488,0.00001453651,0.9995601,0.00002507577,0.00001423112,0.0002292123],"study_design_scores_gemma":[0.000009216894,0.0001265424,0.007655735,0.000007926259,0.00001032021,0.0001000518,0.00004803735,0.0004328786,0.9895328,0.00001657142,0.002056782,0.000003124046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937788,0.002005545,0.001359783,0.00008532393,0.00002181439,0.00001448438,0.0003256505,0.0000552908,0.002353333],"genre_scores_gemma":[0.9951297,0.0006943332,0.001204709,0.00004539155,0.000005863858,0.00001426253,0.0003825178,0.00001176561,0.002511491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522923,"threshold_uncertainty_score":0.005094707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112670296864142,"score_gpt":0.2764322387879273,"score_spread":0.2653055358192859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}