{"id":"W4223463368","doi":"10.3390/pharmaceutics14040828","title":"Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-D-mannitol Analogs","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Glycomics Network","keywords":"Mannitol; In vitro; Chemistry; Transporter; D-mannitol; Molecular dynamics; Biochemistry; Stereochemistry; Gene; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262401,0.0003107373,0.0002814104,0.00007528123,0.00009614925,0.0001816015,0.000308242,0.0002802278,0.0007959468],"category_scores_gemma":[0.0001645571,0.0001180356,0.0002230052,0.000143548,0.00009842435,0.0002073945,0.0001215071,0.0004061603,0.0002111629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003733615,"about_ca_system_score_gemma":0.000123088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001313254,"about_ca_topic_score_gemma":0.00120273,"domain_scores_codex":[0.9999466,0.000009858693,0.000003234877,0.00001323534,0.00001326575,0.00001383622],"domain_scores_gemma":[0.9999576,0.000009030756,0.00001253526,0.000003520195,0.000006734162,0.00001071225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002361182,0.0001797339,0.0002882779,0.000241866,0.00003248547,0.0001650016,0.0000787163,0.01676985,0.9731502,0.001002169,0.0003772884,0.007478294],"study_design_scores_gemma":[0.0000438071,0.00107892,0.0005162245,0.000006889101,0.0000265137,0.000115421,0.00002498997,0.02777774,0.9661072,0.00007893374,0.004200201,0.00002316533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857174,0.002547622,0.009072816,0.0001289845,0.00003516439,0.00006252176,0.0002926198,0.00009419389,0.002048726],"genre_scores_gemma":[0.9883617,0.001493157,0.008544245,0.00004689765,0.0000076829,0.00004942351,0.0003402092,0.00002280738,0.001133904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313254,"threshold_uncertainty_score":0.002708972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0592657873307335,"score_gpt":0.367318212106961,"score_spread":0.3080524247762275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}