{"id":"W4223463368","doi":"10.3390/pharmaceutics14040828","title":"Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-D-mannitol Analogs","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Glycomics Network","keywords":"Mannitol; In vitro; Chemistry; Transporter; D-mannitol; Molecular dynamics; Biochemistry; Stereochemistry; Gene; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001360709,0.0001634527,0.0003121826,0.0002672253,0.0001038584,0.00001204765,0.000143193,0.00003596189,0.00003671634],"category_scores_gemma":[0.0001821719,0.0001437587,0.00009273863,0.0006298239,0.00004857724,0.00005410169,0.00005867107,0.0002744581,0.000001220525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002919995,"about_ca_system_score_gemma":0.0003710507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006186008,"about_ca_topic_score_gemma":0.00002098483,"domain_scores_codex":[0.9981277,0.000188994,0.0003198599,0.0002772871,0.0008230493,0.0002631357],"domain_scores_gemma":[0.9992817,0.00007054414,0.00009741484,0.0002200548,0.0001608624,0.0001694296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.006941141,0.003696968,0.009940038,0.000483411,0.0009640952,0.0001424953,0.01158553,0.05188592,0.7618752,0.001014359,0.0002385232,0.1512323],"study_design_scores_gemma":[0.007459948,0.0001093952,0.01955759,0.0000462986,0.003862237,0.00003727719,0.002892445,0.7423761,0.2218307,0.0001312992,0.001302259,0.0003943913],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934565,0.001567999,0.001331447,0.001104318,0.0001792479,0.001057493,0.0003523708,0.00002296565,0.0009276742],"genre_scores_gemma":[0.9984623,0.00007463362,0.0002426603,0.0008386502,0.00004258968,0.0002128796,0.00008040339,0.00002668743,0.00001917785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6904902,"threshold_uncertainty_score":0.5862311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0592657873307335,"score_gpt":0.367318212106961,"score_spread":0.3080524247762275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}