{"id":"W4223471844","doi":"10.1016/j.immuni.2022.03.017","title":"DC1s shield Tpex cells to bolster PD-1 blockade","year":2022,"lang":"en","type":"letter","venue":"Immunity","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Terry Fox Research Institute","keywords":"Bolster; Blockade; Biology; Shield; Cell biology; Genetics; Receptor; Engineering; Mechanical engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0007255206,0.0008479499,0.001065613,0.0005803503,0.001100458,0.00009801039,0.002132678,0.001887218,0.03778064],"category_scores_gemma":[0.000140815,0.0008392063,0.0005805906,0.0004468649,0.000320985,0.0001301621,0.00101298,0.008094738,0.006992171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002472789,"about_ca_system_score_gemma":0.000290249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001358644,"about_ca_topic_score_gemma":0.00001536536,"domain_scores_codex":[0.9945706,0.002415561,0.000819133,0.0007298384,0.0001646784,0.001300192],"domain_scores_gemma":[0.9962628,0.0009704567,0.0003357712,0.002302708,0.00009473324,0.00003347228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008480141,0.0001299309,0.00000808886,0.00005004327,0.0005700387,0.000105998,0.001032865,0.000002619836,0.2353111,0.000005226313,0.7593511,0.00258506],"study_design_scores_gemma":[0.0009140048,0.0008881754,0.0001303717,0.00007076006,0.0001073905,0.0001632396,0.0002580794,9.18206e-8,0.1347877,0.00003205715,0.8618093,0.0008387977],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1981831,0.04174894,0.0001186998,0.7024942,0.02811154,0.003842243,0.002059695,0.001232105,0.02220945],"genre_scores_gemma":[0.01636909,0.0005004916,0.00007100259,0.6910759,0.000791147,0.0004097467,0.00246157,0.0002704803,0.2880505],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2658411,"threshold_uncertainty_score":0.9994085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01781715319859763,"score_gpt":0.2450892510326442,"score_spread":0.2272720978340466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}