{"id":"W4223471844","doi":"10.1016/j.immuni.2022.03.017","title":"DC1s shield Tpex cells to bolster PD-1 blockade","year":2022,"lang":"en","type":"letter","venue":"Immunity","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Terry Fox Research Institute","keywords":"Bolster; Blockade; Biology; Shield; Cell biology; Genetics; Receptor; Engineering; Mechanical engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00222433,0.0006383354,0.0007522237,0.0003548466,0.001708948,0.002974268,0.0008529404,0.02095017,0.004498745],"category_scores_gemma":[0.007366045,0.0004118224,0.0007473351,0.0001585218,0.002425073,0.001729344,0.001582254,0.02451797,0.003614115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002822854,"about_ca_system_score_gemma":0.00143214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001455879,"about_ca_topic_score_gemma":0.003009759,"domain_scores_codex":[0.9987773,0.0003256365,0.00007059464,0.0001299434,0.0004386699,0.0002578836],"domain_scores_gemma":[0.9979327,0.00131698,0.0001427257,0.0001079262,0.000263151,0.0002365152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002677156,0.0000699716,0.000432836,0.00008823966,0.00003859385,0.00172672,0.00009480366,0.0001945699,0.001789909,0.0171585,0.9444569,0.03368131],"study_design_scores_gemma":[0.000409765,0.0001540876,0.0005191437,0.0001329092,0.00003184997,0.00183579,0.000135717,0.000867892,0.002649315,0.0261967,0.9670331,0.00003372887],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.00230045,0.009691686,0.000776588,0.9351264,0.03552551,0.00004354978,0.00006519541,0.000107304,0.01636323],"genre_scores_gemma":[0.03866304,0.004452419,0.0008078911,0.8669826,0.04798692,0.000123934,0.0000459209,0.00004285314,0.04089438],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02095017,"threshold_uncertainty_score":0.02048141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01781715319859763,"score_gpt":0.2450892510326442,"score_spread":0.2272720978340466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}