{"id":"W4223484562","doi":"10.1016/j.jid.2022.03.013","title":"T Helper 2 IL-4/IL-13 Dual Blockade with Dupilumab Is Linked to Some Emergent T Helper 17‒Type Diseases, Including Seronegative Arthritis and Enthesitis/Enthesopathy, but Not to Humoral Autoimmune Diseases","year":2022,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Leeds Biomedical Research Centre; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"Medicine; Immunology; Spondyloarthropathy; Arthritis; Psoriatic arthritis; Psoriasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002613165,0.000586802,0.001324222,0.0005825983,0.001099003,0.00004692156,0.000471154,0.0002023602,0.0005941728],"category_scores_gemma":[0.0005289903,0.0005211003,0.0002062524,0.0005333238,0.00107793,0.0003888121,0.0007220758,0.000980955,0.0001111416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002455999,"about_ca_system_score_gemma":0.0006975356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001363082,"about_ca_topic_score_gemma":0.00005826442,"domain_scores_codex":[0.9959119,0.001154293,0.001110081,0.0006301873,0.0003022935,0.0008912588],"domain_scores_gemma":[0.9976636,0.0002905818,0.0007324094,0.0003620051,0.0004994052,0.000451963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005097697,0.001237724,0.01353111,0.0001560455,0.002367668,0.003619421,0.04705215,0.0003240751,0.8678247,0.001795842,0.05514986,0.001843725],"study_design_scores_gemma":[0.01032232,0.008198775,0.1562785,0.0008000634,0.0009371624,0.01661333,0.02467635,0.00005657975,0.6740928,0.003008859,0.1028544,0.002160937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803463,0.005229216,0.00004341553,0.007574851,0.001002037,0.0005897745,0.005113604,0.00006127446,0.00003956294],"genre_scores_gemma":[0.9910109,0.0004283913,0.0004186675,0.007275309,0.0001718025,0.00009334213,0.0001330481,0.00006879027,0.0003997391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1937319,"threshold_uncertainty_score":0.999724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02308688575042584,"score_gpt":0.246272804028133,"score_spread":0.2231859182777071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}