{"id":"W4223484562","doi":"10.1016/j.jid.2022.03.013","title":"T Helper 2 IL-4/IL-13 Dual Blockade with Dupilumab Is Linked to Some Emergent T Helper 17‒Type Diseases, Including Seronegative Arthritis and Enthesitis/Enthesopathy, but Not to Humoral Autoimmune Diseases","year":2022,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Leeds Biomedical Research Centre; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"Medicine; Immunology; Spondyloarthropathy; Arthritis; Psoriatic arthritis; Psoriasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008068541,0.0002742551,0.0006045365,0.001437444,0.0003234562,0.0008068125,0.0002549889,0.0002920378,0.002092416],"category_scores_gemma":[0.001810377,0.0001487176,0.001118491,0.002684631,0.0002170201,0.000314313,0.0003797612,0.0003338273,0.0002653737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004761213,"about_ca_system_score_gemma":0.0006120539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002480777,"about_ca_topic_score_gemma":0.004152263,"domain_scores_codex":[0.9990616,0.0001763389,0.0001402491,0.000308629,0.0002073308,0.0001058051],"domain_scores_gemma":[0.9974497,0.0008460717,0.00140847,0.00008983413,0.0001012805,0.0001046174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00166688,0.0001087918,0.9363245,0.001183739,0.001089395,0.001824761,0.0001064169,0.0006132158,0.007185596,0.0002363439,0.001444009,0.04821644],"study_design_scores_gemma":[0.000127857,0.0004765833,0.9706297,0.00022398,0.002474125,0.008199538,0.00022469,0.003617226,0.005798528,0.0005979504,0.007598822,0.00003100549],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798147,0.01061987,0.000958533,0.0002371505,0.00001549863,0.00003901494,0.006859067,0.00008304111,0.001373063],"genre_scores_gemma":[0.9910142,0.002786857,0.0009389486,0.0002072253,0.00002304595,0.00001876485,0.004747013,0.000009075146,0.0002548062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002480777,"threshold_uncertainty_score":0.00699985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02308688575042584,"score_gpt":0.246272804028133,"score_spread":0.2231859182777071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}