{"id":"W4223488488","doi":"10.3389/fimmu.2022.850616","title":"Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada; European Genomic Institute for Diabetes","keywords":"Granzyme; Granzyme B; Cell biology; CXCL10; Biology; Chemokine; Chemistry; Cytotoxic T cell; T cell; Perforin; Molecular biology; Immunology; In vitro; Inflammation; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000252375,0.0002078075,0.0004361937,0.0001737857,0.0001386557,0.000008741041,0.000514258,0.0002238782,0.00009019693],"category_scores_gemma":[0.00003067136,0.000232303,0.0001479739,0.0001514932,0.0001680174,0.00000496405,0.0002337356,0.0003580892,0.000002481231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008416649,"about_ca_system_score_gemma":0.00009261227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004936522,"about_ca_topic_score_gemma":0.00006041728,"domain_scores_codex":[0.9983465,0.0002731508,0.0004443621,0.0003923054,0.0001578652,0.0003858333],"domain_scores_gemma":[0.9993594,0.0000138802,0.0001699792,0.0003695672,0.00004396344,0.00004324454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006204021,0.0002798317,0.01331339,0.00001529032,0.0001676291,0.0000141387,0.0002741787,0.00004640283,0.9843351,0.00006626848,0.0007318566,0.0001355138],"study_design_scores_gemma":[0.003446321,0.0009961078,0.005421128,0.000006533901,0.00002723568,0.00001730012,0.0005992802,0.00007655693,0.9842888,0.0001896816,0.004625431,0.0003056829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909727,0.003150775,0.003572002,0.00004903504,0.001476148,0.000287343,0.0001393465,0.00002067295,0.0003319634],"genre_scores_gemma":[0.9981037,0.0003049074,0.0007122036,0.0001539161,0.00004486078,0.0000546999,0.0002992877,0.00003102992,0.0002953997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007892264,"threshold_uncertainty_score":0.9473042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050994988220065,"score_gpt":0.2149373251894516,"score_spread":0.204427375307251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}