{"id":"W4223489001","doi":"10.1038/s41398-022-01884-3","title":"Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders","year":2022,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Calgary","funders":"Medical Research Council; Alberta Innovates; Academy of Medical Sciences","keywords":"Schizophrenia spectrum; Clozapine; Schizophrenia (object-oriented programming); Psychiatry; Genome-wide association study; Association (psychology); Medicine; Clinical psychology; Psychology; Psychosis; Single-nucleotide polymorphism; Genetics; Psychotherapist; Genotype; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000683619,0.0004292078,0.0003648293,0.0007688649,0.0004121633,0.0004821369,0.0002756765,0.0004212591,0.00187761],"category_scores_gemma":[0.001610316,0.0002472475,0.0008557608,0.000902098,0.0002450828,0.0001460431,0.0003694757,0.000463447,0.0001428246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001838354,"about_ca_system_score_gemma":0.0002093962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007357094,"about_ca_topic_score_gemma":0.008732026,"domain_scores_codex":[0.9994137,0.0002532251,0.00005334751,0.0001542927,0.00007745927,0.00004797466],"domain_scores_gemma":[0.9987996,0.0002951701,0.0005314546,0.0001354627,0.00008566843,0.0001525671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003164729,0.00002108856,0.9963061,0.000006235171,0.0004470619,0.0000832051,0.00003822111,0.0001082163,0.001666614,0.00001804561,0.00008944295,0.0008993726],"study_design_scores_gemma":[0.000009648665,0.00004559287,0.9993116,0.000001438745,0.00008328516,0.00009215645,0.0000258425,0.0003131322,0.00006249746,0.00001449972,0.00003848245,0.000001851245],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993252,0.0001132862,0.0001398431,0.00003963373,0.000003723875,0.000003664946,0.0002473846,0.000006521073,0.0001209586],"genre_scores_gemma":[0.9995608,0.00003482568,0.0001133273,0.00001067768,0.00000432728,0.000003236628,0.0001989508,0.000002312792,0.00007167093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007357094,"threshold_uncertainty_score":0.01462853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077573665011061,"score_gpt":0.2675887024849439,"score_spread":0.2568129658348333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}