{"id":"W4223493609","doi":"10.1101/2022.04.08.487548","title":"Salt stress alters the spectrum of <i>de novo</i> mutation available to selection during experimental adaptation of <i>Chlamydomonas reinhardtii</i>","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mutation rate; Indel; Mutation; Adaptation (eye); Selection (genetic algorithm); Chlamydomonas reinhardtii; Biology; Genetics; Genome; Mutation Accumulation; Mutant; Chlamydomonas; Gene; Computational biology; Genotype; Single-nucleotide polymorphism; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004435511,0.0003056955,0.0004044952,0.0001998436,0.0003096517,0.0004523644,0.0005456302,0.0003380139,0.001067195],"category_scores_gemma":[0.000459554,0.0002464438,0.0002618835,0.0002212594,0.0003843104,0.0002534181,0.0006696619,0.0009189582,0.0002379799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006700953,"about_ca_system_score_gemma":0.0003390415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004105063,"about_ca_topic_score_gemma":0.003746139,"domain_scores_codex":[0.9996439,0.00005985825,0.00004530177,0.00009359142,0.00007318601,0.00008412851],"domain_scores_gemma":[0.9994501,0.0001441191,0.00009955279,0.0001319791,0.00006644585,0.0001076807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008327328,0.00002409628,0.0005777825,0.000009168271,0.000004478754,0.00001369115,0.00002661475,0.00005700405,0.9988146,0.00003564407,0.00002093764,0.0003327708],"study_design_scores_gemma":[0.00001751501,0.0002582499,0.04096023,0.000008195479,0.00001652622,0.0000813359,0.000140239,0.002050378,0.9554265,0.00007522607,0.0009414137,0.00002422781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997851,0.0001067381,0.001101421,0.00006272922,0.00001488404,0.0000175823,0.0003628936,0.00005548619,0.000427331],"genre_scores_gemma":[0.9963856,0.0000854838,0.00149708,0.00008414533,0.000004741928,0.00004073713,0.0005011691,0.000103991,0.001297052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004105063,"threshold_uncertainty_score":0.00816232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007971527500662844,"score_gpt":0.2188026173039166,"score_spread":0.2108310898032538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}