{"id":"W4223503917","doi":"10.3390/cells11081284","title":"Neuroprotective Effects of PARP Inhibitors in Drosophila Models of Alzheimer’s Disease","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Sapienza Università di Roma","keywords":"Neuroprotection; Neuroscience; Disease; Drosophila (subgenus); Alzheimer's disease; Neurodegeneration; Biology; Medicine; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698316,0.0007339987,0.0004399362,0.0005339483,0.0002321674,0.0002987039,0.0003803621,0.0003826489,0.001000977],"category_scores_gemma":[0.00006719206,0.0001734621,0.0004314933,0.0001977497,0.0002041179,0.0002763341,0.0001750453,0.0009799886,0.0002321065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004407899,"about_ca_system_score_gemma":0.0002934402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001192725,"about_ca_topic_score_gemma":0.002214355,"domain_scores_codex":[0.9998393,0.00002279041,0.0000227054,0.00004072921,0.00004880132,0.00002575191],"domain_scores_gemma":[0.9999306,0.00001035569,0.00002097312,0.000006666473,0.00001053642,0.0000208523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003300398,0.0001287678,0.0001158318,0.0001504539,0.00002656074,0.00006456436,0.00001914022,0.000304185,0.9951094,0.0001724107,0.0001472538,0.003431402],"study_design_scores_gemma":[0.0001057026,0.001836252,0.002478576,0.00001684401,0.00007591673,0.0001972607,0.00003150752,0.001101289,0.9903393,0.0000725764,0.003731473,0.00001325278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799788,0.008151533,0.004237643,0.0002833599,0.0001535686,0.0002142945,0.002593748,0.0003122425,0.004074612],"genre_scores_gemma":[0.9792747,0.007090027,0.007631407,0.0001451969,0.00002407051,0.0002956442,0.001538708,0.00003647143,0.003963797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001192725,"threshold_uncertainty_score":0.003348589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02156307673758222,"score_gpt":0.2677628496917756,"score_spread":0.2461997729541934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}