{"id":"W4223509630","doi":"10.1038/s42003-022-03248-5","title":"Identification of genetic effects underlying type 2 diabetes in South Asian and European populations","year":2022,"lang":"en","type":"review","venue":"Communications Biology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; McGill University; Hamilton Health Sciences; McMaster University; Population Health Research Institute","funders":"National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; Biomedical Research Council; National Medical Research Council; Medical Research Council; Fogarty International Center; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; MRC-PHE Centre for Environment and Health; Servier; National Center for Global Health and Medicine; Department of Science and Technology, Ministry of Science and Technology, India; National Institute of Neurological Disorders and Stroke; University of Cambridge; British Heart Foundation; National Institute on Aging; National Institute for Health and Care Research; European Commission; Jawaharlal Nehru University; Council of Scientific and Industrial Research, India; Imperial College Healthcare NHS Trust; Wellcome Trust; National Institutes of Health; Regeneron Pharmaceuticals; Genentech; National Institute for Health Research Health Protection Research Unit; Pfizer; Heart and Stroke Foundation of Canada; GlaxoSmithKline; Imperial College London; American Heart Association; Eli Lilly and Company; Bristol-Myers Squibb; AstraZeneca; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi","keywords":"Type 2 diabetes; Quartile; Genetic association; Biology; Genome-wide association study; Gene; Identification (biology); Genetics; Computational biology; Evolutionary biology; Bioinformatics; Genotype; Diabetes mellitus; Single-nucleotide polymorphism; Medicine; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006592076,0.000199529,0.0006131298,0.0002224775,0.0001724384,0.000008937093,0.0007075309,0.000242032,0.00000940169],"category_scores_gemma":[0.0006758264,0.0002026399,0.0001248246,0.0003164187,0.0002138763,0.000001943817,0.0007632062,0.0002480286,0.000007449854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003645684,"about_ca_system_score_gemma":0.00009838196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000113115,"about_ca_topic_score_gemma":0.00005848258,"domain_scores_codex":[0.9964798,0.002120731,0.000802619,0.0003537644,0.00003582511,0.0002072243],"domain_scores_gemma":[0.9977405,0.0001993876,0.000623654,0.001353283,0.00004393299,0.000039247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002371352,0.0001225144,0.03723043,0.001139266,0.0001996727,4.044465e-7,0.0002285997,0.00001367206,0.000501005,0.0008808704,0.0001233066,0.9595579],"study_design_scores_gemma":[0.0002329034,0.0002417718,0.03599833,0.0002951043,0.0003504817,0.000007597998,0.0001423657,0.0001173836,0.000003684437,0.0007847145,0.9614128,0.0004128063],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005349034,0.9933658,0.0001375366,0.0000526615,0.0001504265,0.0004494747,0.00005858205,0.000009362079,0.0004270895],"genre_scores_gemma":[0.09394868,0.9027283,0.001320989,0.00002507178,0.00002544085,0.0001247092,0.001752751,0.00003296354,0.00004112928],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9612895,"threshold_uncertainty_score":0.8263413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1191726609807301,"score_gpt":0.3790486531685874,"score_spread":0.2598759921878573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}