{"id":"W4223516367","doi":"10.1186/s13063-022-06198-9","title":"Safety, tolerability, and efficacy of monoclonal CD38 antibody felzartamab in late antibody-mediated renal allograft rejection: study protocol for a phase 2 trial","year":2022,"lang":"en","type":"article","venue":"Trials","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"MorphoSys","keywords":"Medicine; Tolerability; Monoclonal antibody; Antibody; CD38; Clinical trial; Protocol (science); Immunology; Pharmacology; Internal medicine; Pathology; Adverse effect; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003059428,0.000219217,0.001278103,0.000258612,0.0001413442,0.00001893377,0.00008334786,0.00006183527,0.0002940856],"category_scores_gemma":[0.0004930315,0.0001696627,0.0002579934,0.0003793634,0.0000494964,0.00006696058,0.00004310639,0.000177772,0.000001369452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007229119,"about_ca_system_score_gemma":0.0001833979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001649513,"about_ca_topic_score_gemma":0.00002181628,"domain_scores_codex":[0.9965339,0.0007846245,0.001579738,0.0004248635,0.0004416078,0.0002352621],"domain_scores_gemma":[0.9977124,0.001395673,0.0004642291,0.0002447041,0.00007793379,0.0001050733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8898321,0.02132192,0.06158019,0.0003776374,0.0009653172,0.0001850753,0.001367211,0.0001692239,0.02163183,0.00005405411,0.00005972414,0.002455686],"study_design_scores_gemma":[0.90578,0.02507667,0.06452616,0.0001681687,0.0005472708,0.00003059574,0.0001421943,0.0003443387,0.00136557,0.0001464171,0.001659753,0.0002128191],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7361471,0.00001095243,0.00008814844,0.0002065835,0.0001407293,0.2630711,0.0002355841,0.0000327722,0.00006697296],"genre_scores_gemma":[0.8446317,0.00001095797,0.000449403,0.00005667133,0.0001943351,0.1537397,0.0006918676,0.00003171913,0.0001936679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1093314,"threshold_uncertainty_score":0.6918645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1237729237190012,"score_gpt":0.4877437489362226,"score_spread":0.3639708252172213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}