{"id":"W4223517548","doi":"10.1002/prp2.949","title":"Inhibition of epigenetic reader proteins by apabetalone counters inflammation in activated innate immune cells from Fabry disease patients receiving enzyme replacement therapy","year":2022,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Resverlogix (Canada)","funders":"","keywords":"Inflammation; Enzyme replacement therapy; Innate immune system; Immune system; Chemokine; Oxidative stress; Peripheral blood mononuclear cell; Globotriaosylceramide; Immunology; Medicine; Biology; Endocrinology; Disease; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054326,0.0002175925,0.0003414278,0.0001356653,0.0001047014,0.0001906406,0.0001107005,0.0001569753,0.001194736],"category_scores_gemma":[0.000144729,0.00007569117,0.0002179052,0.00009975941,0.0001227281,0.00008675548,0.0001357452,0.0004699436,0.0001748974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000934355,"about_ca_system_score_gemma":0.0001210286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002774823,"about_ca_topic_score_gemma":0.0005176851,"domain_scores_codex":[0.9999287,0.00001627154,0.000007643323,0.00001197151,0.00001443186,0.00002097696],"domain_scores_gemma":[0.9999529,0.000008642987,0.0000108762,0.000003879774,0.000005516086,0.00001819376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002319159,0.0001989367,0.0007307422,0.00006862439,0.00001795235,0.00009177793,0.00003865755,0.00006585115,0.9885213,0.00002496633,0.00008909668,0.007833027],"study_design_scores_gemma":[0.0009085491,0.01580277,0.04352748,0.0000209014,0.0001709805,0.001125991,0.0001398765,0.002043673,0.9286311,0.00009964465,0.007509816,0.00001917962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978497,0.001329618,0.0003901176,0.00004561248,0.00002459933,0.00001546445,0.00008062257,0.00002603647,0.0002382973],"genre_scores_gemma":[0.9979949,0.0005641414,0.0004476495,0.0000575846,0.00001362214,0.00002843238,0.0002061077,0.000004392345,0.0006831845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001194736,"threshold_uncertainty_score":0.003996849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03065389944111996,"score_gpt":0.3500248331064114,"score_spread":0.3193709336652914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}