{"id":"W4223525031","doi":"10.1182/blood.2021014735","title":"Long-term follow-up of liver-directed, adeno-associated vector-mediated gene therapy in the canine model of hemophilia A","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Southeastern Ontario Academic Medical Organization; Canadian Institutes of Health Research; BioMarin Pharmaceutical","keywords":"Genetic enhancement; Capsid; Titer; Medicine; Adeno-associated virus; Spleen; Gastroenterology; Virology; Immunology; Internal medicine; Antibody; Biology; Molecular biology; Vector (molecular biology); Virus; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005405794,0.0001574188,0.0002391914,0.00009203622,0.00007473913,0.000006165466,0.0005767035,0.0000985462,0.00008759129],"category_scores_gemma":[0.00007265541,0.0001353823,0.0001305226,0.0003998487,0.00007654335,0.000002462812,0.0001481076,0.0001969975,0.000001109014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002525763,"about_ca_system_score_gemma":0.0002644618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001922896,"about_ca_topic_score_gemma":0.001005808,"domain_scores_codex":[0.998333,0.0003704607,0.0002903141,0.0002873098,0.0004226478,0.0002963154],"domain_scores_gemma":[0.9991651,0.00003871084,0.0001504768,0.0004802608,0.000121335,0.0000440937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001475573,0.001070945,0.009982212,0.00001299672,0.0002303032,0.00001590549,0.0004771231,0.0005666147,0.985724,0.000002540201,0.0001188275,0.00032297],"study_design_scores_gemma":[0.007290649,0.004373282,0.0179137,0.000009391188,0.00003592228,0.00001103204,0.00005237252,0.001013236,0.9690626,0.00001935838,0.00002013649,0.0001983717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956744,0.003464067,0.000005455864,0.00007668234,0.00003593529,0.000413565,0.0002605041,0.00001302446,0.00005635717],"genre_scores_gemma":[0.9981976,0.0008928055,0.00002359352,0.0001370486,0.00003729288,0.0001054987,0.0003810383,0.00003295137,0.000192149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01666145,"threshold_uncertainty_score":0.5520732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02307641239934956,"score_gpt":0.2646365220195952,"score_spread":0.2415601096202456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}