{"id":"W4223525031","doi":"10.1182/blood.2021014735","title":"Long-term follow-up of liver-directed, adeno-associated vector-mediated gene therapy in the canine model of hemophilia A","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Southeastern Ontario Academic Medical Organization; Canadian Institutes of Health Research; BioMarin Pharmaceutical","keywords":"Genetic enhancement; Capsid; Titer; Medicine; Adeno-associated virus; Spleen; Gastroenterology; Virology; Immunology; Internal medicine; Antibody; Biology; Molecular biology; Vector (molecular biology); Virus; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008250275,0.0002596942,0.0007444939,0.0006288032,0.0004381583,0.0006140899,0.0002326318,0.0005040281,0.000806134],"category_scores_gemma":[0.0007519657,0.0001514355,0.0004270843,0.0003017995,0.0003986128,0.000625719,0.000250322,0.000874536,0.0004208628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003646535,"about_ca_system_score_gemma":0.0001627702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004554546,"about_ca_topic_score_gemma":0.0007630257,"domain_scores_codex":[0.9997028,0.00007004179,0.000030684,0.00005345677,0.00005721493,0.00008593813],"domain_scores_gemma":[0.9990342,0.0001760218,0.0002699105,0.0001103241,0.000195844,0.0002138284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01275943,0.006938808,0.1725394,0.0002878208,0.0005024375,0.003599116,0.000842053,0.001790593,0.7387697,0.0003210085,0.0017169,0.05993275],"study_design_scores_gemma":[0.0004719471,0.08650206,0.6037065,0.0001303211,0.001221757,0.01446821,0.001007649,0.006828268,0.2737856,0.0006517586,0.0110665,0.0001594263],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970145,0.001133299,0.000744281,0.00006530372,0.00002125726,0.00002482745,0.0002722845,0.00002432554,0.0006998925],"genre_scores_gemma":[0.9974989,0.0003534339,0.000213919,0.00005457732,0.00001488328,0.00003274609,0.0009780015,0.000006667432,0.0008467354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008250275,"threshold_uncertainty_score":0.004363239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02307641239934956,"score_gpt":0.2646365220195952,"score_spread":0.2415601096202456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}