{"id":"W4223529834","doi":"10.1038/s41598-022-09825-2","title":"Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90","year":2022,"lang":"en","type":"review","venue":"Scientific Reports","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; University of California, Irvine; University of California, San Francisco; National Institute of Biomedical Imaging and Bioengineering; University of California, Los Angeles; National Institutes of Health; Medical Research Council; Hersenstichting; National Cancer Institute; Stichting MS Research; Newcastle University; U.S. Department of Defense; BrightFocus Foundation; Eli Lilly and Company; Alzheimer's Research Trust; Johns Hopkins University; University of Washington; York University; Biogen; University of Miami; BioClinica; Northwestern University; Emory University; University of Pennsylvania; Vanderbilt University; North Bristol NHS Trust; Bristol-Myers Squibb; University of California, Davis; Eisai; Howard Hughes Medical Institute; Massachusetts General Hospital; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; University of California, San Diego; U.S. Department of Veterans Affairs; Office of Research and Development; Alzheimer's Association; Wellcome Trust; University of Southern California; Universitat de Barcelona; Rush University","keywords":"Genome-wide association study; SNP; Single-nucleotide polymorphism; Biology; Disease; Genetics; Genetic association; Allele; Bioinformatics; Medicine; Genotype; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005004522,0.0003278868,0.0003175881,0.0007346198,0.0004140547,0.0004873955,0.0001667389,0.00027009,0.0009707484],"category_scores_gemma":[0.001296742,0.0001671192,0.0004294076,0.0008488772,0.0002188952,0.0001716414,0.0004417516,0.0003209561,0.0001874482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001411149,"about_ca_system_score_gemma":0.0001181218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004152626,"about_ca_topic_score_gemma":0.005075279,"domain_scores_codex":[0.9995721,0.0001215997,0.00004594539,0.0001599606,0.00005302624,0.00004734918],"domain_scores_gemma":[0.9994661,0.0001090017,0.0001884077,0.00009213098,0.00007248857,0.00007196508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003982444,0.00002810452,0.9930709,0.000009742489,0.0002494019,0.0001616654,0.00008822636,0.00004944578,0.003293853,0.00002525049,0.0001407215,0.002484453],"study_design_scores_gemma":[0.000003526033,0.00003804834,0.9993012,0.000001139162,0.00005633035,0.000163755,0.00003710809,0.00008486734,0.0001822161,0.00002382574,0.0001063141,0.000001623107],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9990458,0.0001572895,0.0001796784,0.00002379817,0.000002777589,0.000003208176,0.0004056035,0.000006379854,0.0001754904],"genre_scores_gemma":[0.9993119,0.00005311244,0.0001687173,0.0000240248,0.000004502706,0.000004027522,0.0003026678,0.000002772009,0.0001281747],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004152626,"threshold_uncertainty_score":0.008256912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05009289544519634,"score_gpt":0.3547066604719683,"score_spread":0.304613765026772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}