{"id":"W4223530014","doi":"10.1016/j.cmet.2022.03.009","title":"Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection","year":2022,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; Mega-projects of Science Research for the 10th Five-Year Plan; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; International Microbiome Centre, University of Calgary; National Cancer Institute; National Institutes of Health; National Heart, Lung, and Blood Institute; Alberta Innovates; National Center for Research Resources; Canterbury Medical Research Foundation; Canada Foundation for Innovation; Georgia Clinical and Translational Science Alliance","keywords":"Immune system; Lipopolysaccharide; Microbiology; Bacteria; Inflammation; Host (biology); Secretion; Pneumonia; Immunology; Sepsis; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002460165,0.000284998,0.00031677,0.0001084245,0.0003078518,0.00006870602,0.0004132731,0.0001130937,0.0001432883],"category_scores_gemma":[0.00003720072,0.0002930264,0.0001366955,0.0002960606,0.00006141092,0.00001322075,0.000442488,0.0002270678,0.00003558658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001682719,"about_ca_system_score_gemma":0.00007639023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008537922,"about_ca_topic_score_gemma":0.00002207911,"domain_scores_codex":[0.9981617,0.0001995766,0.000259151,0.0006467918,0.0003056747,0.0004271037],"domain_scores_gemma":[0.9990062,0.00001286146,0.0001604386,0.0006105879,0.00006575274,0.0001441672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005819651,0.0001720187,0.02202701,0.00002861567,0.00003299437,0.0000105009,0.0001226267,0.0001583179,0.9750953,0.00006924777,0.0005285207,0.001696692],"study_design_scores_gemma":[0.0001821101,0.00005953315,0.1680773,0.000007168479,0.00003834033,0.00001800513,0.0001213579,0.00001248338,0.6298118,0.00002780381,0.201335,0.0003091452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903278,0.005133478,0.0001473951,0.0001602261,0.001364105,0.0004606786,0.0001077838,0.00004039681,0.002258185],"genre_scores_gemma":[0.9952103,0.0006205958,0.0003783729,0.0003568042,0.0005496611,0.0001021169,0.0001152932,0.00005763675,0.002609223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3452834,"threshold_uncertainty_score":0.9999522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045044325695305,"score_gpt":0.2305558130343288,"score_spread":0.2201053697773757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}