{"id":"W4223530014","doi":"10.1016/j.cmet.2022.03.009","title":"Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection","year":2022,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; Mega-projects of Science Research for the 10th Five-Year Plan; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; International Microbiome Centre, University of Calgary; National Cancer Institute; National Institutes of Health; National Heart, Lung, and Blood Institute; Alberta Innovates; National Center for Research Resources; Canterbury Medical Research Foundation; Canada Foundation for Innovation; Georgia Clinical and Translational Science Alliance","keywords":"Immune system; Lipopolysaccharide; Microbiology; Bacteria; Inflammation; Host (biology); Secretion; Pneumonia; Immunology; Sepsis; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638389,0.0003465421,0.0003603943,0.0001968685,0.0002268932,0.0002971496,0.0001584788,0.0003752867,0.001270313],"category_scores_gemma":[0.0001863739,0.0001886112,0.0003024196,0.0001427186,0.0002259864,0.0001414074,0.0003651283,0.0006466614,0.0002615078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002423518,"about_ca_system_score_gemma":0.0002098237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004825923,"about_ca_topic_score_gemma":0.0008871944,"domain_scores_codex":[0.9997361,0.000069879,0.00002042892,0.00002941346,0.00004394182,0.0001002346],"domain_scores_gemma":[0.9997674,0.00004325577,0.00004457101,0.00003489955,0.00002629712,0.00008354275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003719714,0.00003102377,0.0002840595,0.00001855764,0.000002519891,0.0001003339,0.00001402847,0.00001796885,0.9986807,0.00002944418,0.00002310131,0.0004264197],"study_design_scores_gemma":[0.00003736969,0.001675099,0.03639147,0.00001055648,0.0000181189,0.0006944209,0.0001769662,0.0004184858,0.9592571,0.00008403628,0.001225359,0.00001111809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968918,0.0008642856,0.0007092847,0.000121564,0.00003477886,0.00002142181,0.0001287878,0.00005635581,0.001171737],"genre_scores_gemma":[0.9983566,0.0002325755,0.0003190454,0.00005584693,0.00001200952,0.00001515012,0.0001307521,0.000009675447,0.0008682656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270313,"threshold_uncertainty_score":0.004249632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045044325695305,"score_gpt":0.2305558130343288,"score_spread":0.2201053697773757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}