{"id":"W4223548728","doi":"10.1126/sciadv.abl4370","title":"Development of iPSC-based clinical trial selection platform for patients with ultrarare diseases","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Clinical trial; Medicine; Induced pluripotent stem cell; Clinical efficacy; Drug; Intensive care medicine; Personalized medicine; Efficacy; Drug development; Bioinformatics; Internal medicine; Oncology; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001759066,0.00005352308,0.0000681586,0.00003169615,0.0002012025,0.000006279464,0.0001387933,0.0000111735,0.000005221986],"category_scores_gemma":[0.00007463392,0.0000444406,0.00002953268,0.0001493587,0.00009443087,0.000007422801,0.00003007953,0.00002577106,9.64158e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001259617,"about_ca_system_score_gemma":0.0002713316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":2.354709e-7,"about_ca_topic_score_gemma":0.000004643175,"domain_scores_codex":[0.9993108,0.0000052481,0.0001547998,0.0002087281,0.0001941955,0.000126263],"domain_scores_gemma":[0.9997327,0.00001462948,0.00006299475,0.00008039972,0.00006847776,0.00004079589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04444001,0.002341818,0.2096794,0.0001832271,0.0000758386,5.186344e-7,0.000291855,0.09071027,0.2032911,0.00007349469,0.0002604723,0.448652],"study_design_scores_gemma":[0.03466258,0.009601435,0.06817032,0.00002215286,0.00003713646,9.083765e-7,0.000517516,0.0009913517,0.7706978,0.00005278784,0.1146893,0.0005566976],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889064,0.0001071333,0.0104354,0.000003994411,0.0002267096,0.0002716928,0.00002227889,0.000005383735,0.00002103182],"genre_scores_gemma":[0.986599,0.00000212717,0.01318027,0.00002133657,0.00004134249,0.00008315896,0.00005115135,0.000004219773,0.00001743793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5674067,"threshold_uncertainty_score":0.1812235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561301054754369,"score_gpt":0.3503631438803566,"score_spread":0.3347501333328128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}