{"id":"W4223548728","doi":"10.1126/sciadv.abl4370","title":"Development of iPSC-based clinical trial selection platform for patients with ultrarare diseases","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Clinical trial; Medicine; Induced pluripotent stem cell; Clinical efficacy; Drug; Intensive care medicine; Personalized medicine; Efficacy; Drug development; Bioinformatics; Internal medicine; Oncology; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004778004,0.0003318612,0.0005605657,0.0007452687,0.0003042386,0.001108503,0.0006189272,0.0007186387,0.003448419],"category_scores_gemma":[0.003957818,0.0002296192,0.00036982,0.0002887416,0.0003140644,0.0004956673,0.0007614154,0.0009437369,0.0009880564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002366955,"about_ca_system_score_gemma":0.0008090821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009547107,"about_ca_topic_score_gemma":0.000178754,"domain_scores_codex":[0.9985155,0.0006473116,0.0001995421,0.0001725991,0.0003476905,0.0001172965],"domain_scores_gemma":[0.9981759,0.0007308728,0.0002691291,0.0003511468,0.000236486,0.0002365242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006213358,0.001707292,0.0285579,0.00102947,0.0004621678,0.006328055,0.0008110005,0.00862898,0.4635886,0.008879441,0.02245964,0.4513341],"study_design_scores_gemma":[0.004644539,0.01339627,0.03662804,0.0005770404,0.001210838,0.02057348,0.0004408377,0.04185174,0.6611056,0.01163184,0.2077316,0.0002081095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7502752,0.008635729,0.1928424,0.004697659,0.001264677,0.009274694,0.005109485,0.002726815,0.0251733],"genre_scores_gemma":[0.8677856,0.003297872,0.110549,0.003101393,0.0004992689,0.0056207,0.004982776,0.0002840841,0.003879444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004778004,"threshold_uncertainty_score":0.02526879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561301054754369,"score_gpt":0.3503631438803566,"score_spread":0.3347501333328128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}