{"id":"W4223553387","doi":"10.1016/j.ccell.2022.03.011","title":"Breaching B cell tolerance in the tumor microenvironment","year":2022,"lang":"en","type":"letter","venue":"Cancer Cell","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research","keywords":"Autoantibody; Autoimmunity; Tumor microenvironment; Immune tolerance; Immune system; Matrix metalloproteinase; Cancer; Biology; Immunology; Ovarian cancer; Peripheral tolerance; Cancer research; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002386098,0.0003831356,0.0004514708,0.00006191314,0.0002506197,0.00001906363,0.000922794,0.0004638404,0.01132173],"category_scores_gemma":[0.000002228699,0.0002962729,0.0001752024,0.0001047083,0.0001596623,0.00003169696,0.0001758397,0.003357932,0.0002251865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004820941,"about_ca_system_score_gemma":0.0001306476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002625804,"about_ca_topic_score_gemma":0.0003276078,"domain_scores_codex":[0.9976017,0.0006030993,0.0003509246,0.0006705736,0.0000656905,0.0007080067],"domain_scores_gemma":[0.9989974,0.0001329597,0.0002523605,0.0005990032,0.000008860844,0.000009411475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004454201,0.00007396381,0.0004445978,0.000105206,0.00002628875,0.0001475275,0.0008242861,0.00004134721,0.02451962,0.000001639193,0.9730116,0.0007593968],"study_design_scores_gemma":[0.0007312522,0.0001436377,0.0003578143,0.00002249903,0.00004978129,0.00007040273,0.0003075219,5.667708e-7,0.005810058,0.00001267398,0.9921544,0.0003394016],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1817995,0.3665032,0.00001768286,0.370451,0.01484293,0.002385113,0.001391486,0.0001381832,0.06247092],"genre_scores_gemma":[0.09529821,0.003162306,0.00001273639,0.873073,0.001213494,0.001046785,0.0008602316,0.00008432106,0.02524896],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.5026219,"threshold_uncertainty_score":0.9999489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008430131390014393,"score_gpt":0.2059073512005499,"score_spread":0.1974772198105355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}