{"id":"W4223562615","doi":"10.1371/journal.pone.0261165","title":"A genome-wide screen for variants influencing certolizumab pegol response in a moderate to severe rheumatoid arthritis population","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"UCB Pharma; UCB","keywords":"Certolizumab pegol; Medicine; Single-nucleotide polymorphism; Genome-wide association study; Rheumatoid arthritis; Population; Psoriatic arthritis; Arthritis; Internal medicine; Immunology; Oncology; Etanercept; Genotype; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006412055,0.0004031117,0.0004444289,0.0005526351,0.0004770612,0.0005019215,0.0003353147,0.0006689819,0.001550202],"category_scores_gemma":[0.001648995,0.0002059027,0.0005689982,0.0009410179,0.0003058425,0.0001172668,0.0003182637,0.0004099143,0.0001931796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001186065,"about_ca_system_score_gemma":0.0002108244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002114321,"about_ca_topic_score_gemma":0.003088065,"domain_scores_codex":[0.9993284,0.0002158977,0.00006354212,0.0002540093,0.00007150968,0.00006680205],"domain_scores_gemma":[0.999369,0.0002849525,0.0001277651,0.00007798322,0.0000444316,0.00009600593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006163288,0.0002703889,0.9233404,0.0001101071,0.001870468,0.002467304,0.0004612136,0.000598278,0.05251826,0.0001728782,0.0007359043,0.01129149],"study_design_scores_gemma":[0.0001730659,0.0005766408,0.9950211,0.000008763281,0.0006339742,0.001135753,0.0001281447,0.0005668796,0.0009085132,0.00008269058,0.0007524373,0.00001211142],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990517,0.0001544598,0.0002202016,0.00004531584,0.000005094261,0.00001364769,0.0003357085,0.000007395365,0.0001663381],"genre_scores_gemma":[0.999183,0.00004794099,0.0002148492,0.00005311187,0.000008357354,0.000009459851,0.0003565473,0.00000480145,0.0001219422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002114321,"threshold_uncertainty_score":0.005185902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03400477629190939,"score_gpt":0.2596520123788832,"score_spread":0.2256472360869738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}