{"id":"W4223564674","doi":"10.1073/pnas.2117435119","title":"A molecular complex of Ca <sub>v</sub> 1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation–transcription coupling","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Salt Science Research Foundation","keywords":"Caveolae; Cell biology; Myocyte; Intracellular; Depolarization; Coupling (piping); Biology; Vascular smooth muscle; Chemotaxis; Transcription (linguistics); Transcription factor; Biophysics; Chemistry; Signal transduction; Gene; Biochemistry; Endocrinology; Materials science; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001608458,0.0001047264,0.0001669124,0.0001915343,0.0002087108,0.00001131638,0.0004994315,0.00007755086,0.000005128421],"category_scores_gemma":[0.0002386092,0.00009710775,0.0001442649,0.0006158386,0.0002583694,0.00002603436,0.0001323364,0.0001167008,1.028234e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002977545,"about_ca_system_score_gemma":0.000126202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001316067,"about_ca_topic_score_gemma":7.303091e-7,"domain_scores_codex":[0.9982954,0.00001011561,0.000419804,0.000310001,0.000798831,0.0001658551],"domain_scores_gemma":[0.9991392,0.00003450032,0.0003516042,0.00001799434,0.0004316614,0.00002507869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008712098,0.00005145969,0.0002697837,0.0001334325,0.00001894883,9.937324e-9,0.0001591283,0.01339057,0.9838353,0.001835999,0.0001113725,0.0001068069],"study_design_scores_gemma":[0.000364577,0.0001083038,0.0009033005,0.00003358933,0.00001798993,0.000005764105,0.0003043774,0.03346005,0.950556,0.01391328,0.0002308337,0.000101867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975883,0.0007644684,0.0004776054,0.0006419058,0.00001859059,0.0002990022,0.00005063615,0.000003402413,0.0001561193],"genre_scores_gemma":[0.9982817,0.00007615976,0.001275847,0.0002562435,0.00003105889,0.00004739431,0.000006122537,0.000009195438,0.00001633047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03327931,"threshold_uncertainty_score":0.3959939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03425683272324545,"score_gpt":0.286131814673712,"score_spread":0.2518749819504665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}