{"id":"W4223568473","doi":"10.1016/j.jbc.2022.101901","title":"Antigen binding by conformational selection in near-germline antibodies","year":2022,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Austrian Science Fund","keywords":"Germline; Epitope; Complementarity determining region; Antigen; Antibody; Complementarity (molecular biology); Affinity maturation; Computational biology; Biology; Mechanism (biology); Genetics; Monoclonal antibody; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000106846,0.0001786176,0.0001592092,0.00009083132,0.000142894,0.0003048579,0.0002638796,0.0002216308,0.001174155],"category_scores_gemma":[0.000125724,0.000126126,0.0001489793,0.0001159483,0.0002610317,0.0001929852,0.0002929187,0.0003341228,0.0002151536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000208775,"about_ca_system_score_gemma":0.0001291939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005970943,"about_ca_topic_score_gemma":0.001002937,"domain_scores_codex":[0.9998957,0.00001515285,0.000003289684,0.00002570392,0.00003183817,0.00002823268],"domain_scores_gemma":[0.9999639,0.00000708715,0.00001002105,0.000003460971,0.000004723383,0.00001076079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008040342,0.00002411739,0.001407635,0.00004060818,0.00001966031,0.0002300632,0.00004779887,0.002649405,0.9874157,0.002227055,0.0002313401,0.005626243],"study_design_scores_gemma":[0.0001166582,0.0005460925,0.01137047,0.00001496859,0.00003855074,0.001306569,0.00014635,0.02396034,0.9480603,0.002448876,0.01195292,0.00003802168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99184,0.0004579556,0.005021424,0.00006156207,0.0000100341,0.000007400277,0.00003131947,0.00006255145,0.002507716],"genre_scores_gemma":[0.9982603,0.0001152478,0.00095517,0.00005385122,0.000002236631,0.00000311883,0.00003516602,0.000004085729,0.0005707729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001174155,"threshold_uncertainty_score":0.003927946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03317255967246522,"score_gpt":0.3155631180921487,"score_spread":0.2823905584196834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}