{"id":"W4223574847","doi":"10.1042/bcj20210528","title":"Allosteric pluripotency: challenges and opportunities","year":2022,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Allosteric regulation; Allosteric enzyme; Induced pluripotent stem cell; Allosteric modulator; Drug discovery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003955302,0.000512624,0.0009868409,0.0005098947,0.0008987281,0.002536452,0.001328032,0.002501779,0.003190783],"category_scores_gemma":[0.002251424,0.000343236,0.0004488604,0.0004844927,0.005755595,0.007038787,0.002303891,0.004326413,0.0009545812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00111563,"about_ca_system_score_gemma":0.001679675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002242688,"about_ca_topic_score_gemma":0.0004567106,"domain_scores_codex":[0.9993655,0.0001777715,0.00004592057,0.0001155075,0.0001687329,0.0001266335],"domain_scores_gemma":[0.998154,0.001022947,0.000158456,0.0001995633,0.0002048717,0.0002600451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002960241,0.0001687393,0.001873274,0.001317104,0.00003994397,0.001833443,0.0009694341,0.003365782,0.05977508,0.6796657,0.009081839,0.2416136],"study_design_scores_gemma":[0.00005914695,0.0006726782,0.001444772,0.0004268859,0.00004823103,0.002978305,0.003380498,0.006190704,0.03487703,0.7196911,0.2301156,0.0001149001],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1625439,0.4383219,0.1290463,0.2159476,0.002918938,0.0001387607,0.0004786676,0.0009964214,0.04960756],"genre_scores_gemma":[0.6442034,0.2908681,0.03590131,0.01501033,0.002864579,0.0002990627,0.0003892767,0.000133486,0.01033056],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003955302,"threshold_uncertainty_score":0.02091789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03973726066334828,"score_gpt":0.235365552642377,"score_spread":0.1956282919790288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}