{"id":"W4223577875","doi":"10.1080/10717544.2022.2035855","title":"Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3","year":2022,"lang":"en","type":"article","venue":"Drug Delivery","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; The Scarborough Hospital; Sunnybrook Hospital; University of Toronto","funders":"Focused Ultrasound Foundation","keywords":"Gene delivery; Drug delivery; Genetic enhancement; Medicine; Blood–brain barrier; Cancer research; Microbubbles; Biology; Chemistry; Central nervous system; Ultrasound; Gene; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655732,0.0004081495,0.0002213615,0.000303128,0.0001432245,0.0003244693,0.0003651289,0.0005117201,0.0009293871],"category_scores_gemma":[0.0001069224,0.0001660203,0.0003894538,0.000131114,0.0003002079,0.000227821,0.0002362403,0.0004224227,0.000367749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000649191,"about_ca_system_score_gemma":0.0003365079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176156,"about_ca_topic_score_gemma":0.00126939,"domain_scores_codex":[0.999855,0.00001569904,0.000008191419,0.0000461763,0.00005085443,0.00002389056],"domain_scores_gemma":[0.9999468,0.000005210152,0.00002190017,0.000004842974,0.000009671543,0.00001154239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005890182,0.00003010937,0.0001061826,0.00003972841,0.000008768394,0.00004507377,0.00001599357,0.0002523627,0.9964433,0.0003362077,0.00006923612,0.002594133],"study_design_scores_gemma":[0.00002039023,0.0002572948,0.0005441997,0.000003509178,0.00001717581,0.0001645379,0.000004332529,0.00149057,0.9939061,0.00004178588,0.003544719,0.000005414582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478474,0.003530549,0.04350634,0.0002317521,0.00009766751,0.0001974884,0.0003811915,0.0004674874,0.003740201],"genre_scores_gemma":[0.9717197,0.001002918,0.02177468,0.0000757534,0.00001935877,0.0001207089,0.0004240821,0.00004964165,0.004813357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001176156,"threshold_uncertainty_score":0.004710197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004889173905903636,"score_gpt":0.1741364234816318,"score_spread":0.1692472495757281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}