{"id":"W4223578727","doi":"10.1053/j.gastro.2022.04.011","title":"Failure to Achieve Target Drug Concentrations During Induction and Not HLADQA1∗05 Carriage Is Associated With Antidrug Antibody Formation in Patients With Inflammatory Bowel Disease: Is HLADQA1∗05 Gone Before It’s Here?","year":2022,"lang":"en","type":"letter","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Infliximab; Medicine; Immunogenicity; Inflammatory bowel disease; Context (archaeology); Internal medicine; Dosing; Gastroenterology; Tumor necrosis factor alpha; Disease; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001741047,0.0005256993,0.001170488,0.0005993993,0.001333991,0.001404301,0.0008860349,0.01739333,0.002472035],"category_scores_gemma":[0.013468,0.0004926238,0.000820704,0.0006283224,0.001255815,0.001388038,0.0004174005,0.01106196,0.00195198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001817362,"about_ca_system_score_gemma":0.001457668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003757162,"about_ca_topic_score_gemma":0.004578806,"domain_scores_codex":[0.9983484,0.0005234535,0.0003229334,0.0002112693,0.0003103829,0.0002836921],"domain_scores_gemma":[0.993361,0.003808097,0.0006984345,0.0002281069,0.0007867264,0.001117595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.001310826,0.0004612906,0.1053637,0.0002625272,0.000244456,0.1093178,0.0004947567,0.0002967952,0.001689108,0.00348879,0.7292206,0.04784942],"study_design_scores_gemma":[0.001494995,0.001962643,0.1534917,0.001304019,0.0006893233,0.2436594,0.002012572,0.006715463,0.002218842,0.02050291,0.5655765,0.0003717304],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.01760804,0.002776725,0.0003001551,0.954544,0.01743661,0.00001484499,0.0001284016,0.00004818575,0.007143022],"genre_scores_gemma":[0.1573332,0.002768585,0.0006802612,0.728002,0.1021926,0.00003859941,0.0001302643,0.00005188944,0.008802491],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.01739333,"threshold_uncertainty_score":0.01318592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003093854370292179,"score_gpt":0.1942730837945781,"score_spread":0.1911792294242859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}