{"id":"W4223597305","doi":"10.1210/clinem/dgac220","title":"Efficacy and Safety of Weekly Somatrogon vs Daily Somatropin in Children With Growth Hormone Deficiency: A Phase 3 Study","year":2022,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"OPKO Health","keywords":"Somatropin; Growth hormone deficiency; Growth hormone; Phase (matter); Medicine; Hormone; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002666206,0.001481305,0.003135875,0.0005215983,0.0005154003,0.0009569957,0.001154103,0.001722936,0.00365168],"category_scores_gemma":[0.001820763,0.0006227559,0.002736064,0.0004399249,0.00135162,0.0009637824,0.0004708262,0.003042602,0.0005302244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001100415,"about_ca_system_score_gemma":0.001741815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085445,"about_ca_topic_score_gemma":0.00199136,"domain_scores_codex":[0.9987428,0.0006832747,0.00007443559,0.0001801871,0.0001353303,0.0001839791],"domain_scores_gemma":[0.9978935,0.0006068449,0.0005682374,0.0002272992,0.0001144219,0.0005896215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.945558,0.0266945,0.002021256,0.000336054,0.0006880634,0.00006455287,0.0001027662,0.0003946815,0.005508385,0.00004533,0.0002940297,0.01829254],"study_design_scores_gemma":[0.6212711,0.3702775,0.006503058,0.00002362396,0.000320786,0.0000763952,0.00003282644,0.0002685086,0.0008489343,0.00006054693,0.0003000741,0.00001652912],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967989,0.001000326,0.0002426041,0.0001248888,0.00005355472,0.001079905,0.0003515117,0.00004363895,0.0003045016],"genre_scores_gemma":[0.9927134,0.001115313,0.001403844,0.0004175001,0.0001682127,0.002646136,0.0007452389,0.0000236651,0.0007667806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00365168,"threshold_uncertainty_score":0.01410043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02515472113237171,"score_gpt":0.3319711121524072,"score_spread":0.3068163910200354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}