{"id":"W4223604056","doi":"10.1126/sciimmunol.abn6660","title":"Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation","year":2022,"lang":"en","type":"article","venue":"Science Immunology","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Human virome; Biology; Inflammatory bowel disease; Innate immune system; Immunology; Colitis; Ulcerative colitis; Microbiome; Phenotype; Disease; Inflammation; Virology; Immune system; Genetics; Metagenomics; Gene; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008720628,0.0002063567,0.0001065251,0.0001206851,0.00006726579,0.0002390775,0.00005131536,0.0001561215,0.0006080829],"category_scores_gemma":[0.0001218912,0.0000667122,0.00009690163,0.00005899933,0.0001776098,0.00009762702,0.0001805175,0.0002281753,0.0001148514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001039616,"about_ca_system_score_gemma":0.00006697616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007988656,"about_ca_topic_score_gemma":0.0001714528,"domain_scores_codex":[0.999921,0.00001798636,0.000005429374,0.00001773462,0.00001697072,0.00002086594],"domain_scores_gemma":[0.999948,0.000008059782,0.0000167933,0.000007081396,0.000004859306,0.00001511949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001509871,0.00001536149,0.001781635,0.00001712023,0.000002683659,0.00003863005,0.00001436359,0.00002865774,0.9963198,0.00005703535,0.00001530046,0.001558475],"study_design_scores_gemma":[0.0000316085,0.001305728,0.1215434,0.00002237587,0.00004172493,0.001665571,0.0002612752,0.001417939,0.8700346,0.0003601312,0.003303102,0.00001245411],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983271,0.0006070064,0.0005085685,0.00002398659,0.000005716985,0.000004483809,0.0000476283,0.00001269914,0.0004628191],"genre_scores_gemma":[0.9986634,0.0003006937,0.000462309,0.00002168435,0.000002859244,0.000004483661,0.00007953825,0.000004508749,0.0004606353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006080829,"threshold_uncertainty_score":0.002034247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01421242833491608,"score_gpt":0.2588040064935382,"score_spread":0.2445915781586221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}