{"id":"W4223604229","doi":"10.1038/s42003-022-03282-3","title":"The intra-mitochondrial O-GlcNAcylation system rapidly modulates OXPHOS function and ROS release in the heart","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Walloon excellence in life sciences and biotechnology; Servier; Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture; Fonds De La Recherche Scientifique - FNRS","keywords":"Mitochondrion; Oxidative phosphorylation; Cell biology; Function (biology); Biology; Cytoplasm; Biochemistry; In vitro; Reactive oxygen species; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264405,0.0003481069,0.0002242632,0.0001089173,0.0001130849,0.0002316279,0.0001422806,0.0001994332,0.0007076316],"category_scores_gemma":[0.0001070269,0.0001042528,0.0001941236,0.00009546479,0.0002001983,0.0002505823,0.0001694072,0.0005084787,0.0001384282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978887,"about_ca_system_score_gemma":0.0001295207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003575193,"about_ca_topic_score_gemma":0.0005673973,"domain_scores_codex":[0.9999325,0.00001431935,0.000004203393,0.00001682279,0.00001192172,0.00002026638],"domain_scores_gemma":[0.9999479,0.000005260424,0.00001592832,0.000006893128,0.000005892767,0.00001806624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002300909,0.00001109179,0.0002447616,0.00001503194,0.000004385215,0.00002120492,0.000008575189,0.00001530097,0.9990133,0.00002329396,0.000008390912,0.0004045253],"study_design_scores_gemma":[0.00001833347,0.0005354136,0.02510748,0.000006957088,0.00002552152,0.000160541,0.00006196293,0.0006818942,0.9724777,0.00008339614,0.0008349681,0.000005926394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964317,0.001590356,0.001331274,0.00007022636,0.00002289178,0.00001084094,0.0001203154,0.00001963305,0.0004028248],"genre_scores_gemma":[0.9969344,0.0008268154,0.0009461179,0.00004646555,0.00001302476,0.00001174369,0.0002628471,0.000009750999,0.0009487363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007076316,"threshold_uncertainty_score":0.002367258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820231879904047,"score_gpt":0.2840008317914319,"score_spread":0.2657985129923914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}