{"id":"W4223604229","doi":"10.1038/s42003-022-03282-3","title":"The intra-mitochondrial O-GlcNAcylation system rapidly modulates OXPHOS function and ROS release in the heart","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Walloon excellence in life sciences and biotechnology; Servier; Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture; Fonds De La Recherche Scientifique - FNRS","keywords":"Mitochondrion; Oxidative phosphorylation; Cell biology; Function (biology); Biology; Cytoplasm; Biochemistry; In vitro; Reactive oxygen species; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006651827,0.00008167795,0.00007931454,0.00005806285,0.001045979,0.00004073964,0.0006147024,0.00007348196,0.00001111384],"category_scores_gemma":[0.0001569626,0.00005684191,0.00003862302,0.0002052005,0.0002200776,0.000004623224,0.0004759844,0.0002799413,0.00000684452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003370724,"about_ca_system_score_gemma":0.00005925606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009697206,"about_ca_topic_score_gemma":0.0002757255,"domain_scores_codex":[0.998167,0.00116708,0.0002139944,0.0001919587,0.00008995907,0.0001699627],"domain_scores_gemma":[0.9985775,0.0001604112,0.00006594342,0.001108316,0.00006026994,0.0000275496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001261499,0.0004023369,0.03160022,0.0000336085,0.0001160061,0.000001333724,0.0007090138,0.0009859701,0.8463581,0.07706594,0.009633228,0.03183272],"study_design_scores_gemma":[0.001814652,0.0009475343,0.03830905,0.000009055385,0.0000212814,0.00009064095,0.003888763,0.01704485,0.002832405,0.002309381,0.932448,0.0002844306],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733341,0.007846911,0.001394585,0.01405487,0.0003482817,0.001443118,0.00004343002,0.00003440271,0.001500323],"genre_scores_gemma":[0.9981083,0.0003499693,0.0001881959,0.0002841451,0.00007138751,0.0005388138,0.0003455203,0.000008396757,0.0001052182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9228147,"threshold_uncertainty_score":0.8044928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820231879904047,"score_gpt":0.2840008317914319,"score_spread":0.2657985129923914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}